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Editors' Choice

Each month, the ONE Editors review leading journals to bring you concise summaries of the most clinically significant studies recently published. Some selections also include commentary from the ONE Editors, recognized leaders in their subspecialty.

All Journal Studies section content represents the opinions of the contributing authors and does not imply endorsement by the American Academy of Ophthalmology.
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Cornea/External Disease
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1-50 of 354 results

Cataract, corneal surgeries most likely to result in ophthalmology malpractice claims

MAY 14, 2018 By Bryan S Lee, MD JD

This review of data from the Physician Insurers Association of America professional liability registry examined claims against ophthalmologists over a 10-year period.

Editors' Choice

Comments 0

Views 886

Repeat cultures may guide treatment of severe fungal keratitis

MAY 10, 2018 By Wuqaas M Munir MD

This secondary analysis of the Mycotic Ulcer Treatment Trial II (MUTT II) found that patients with a positive 6-day fungal culture carry a high risk of corneal perforation.

Editors' Choice

Comments 0

Views 663

Riboflavin dosing intervals do not impact CXL outcomes

APR 27, 2018 By Rahul T Pandit MD

This prospective, randomized trial compared the effectiveness of 2 riboflavin dosing intervals for corneal crosslinking (CXL).

Editors' Choice

Comments 0

Views 529

Novel treatment restores corneal clarity in patients with bullous keratopathy

APR 17, 2018 By Julie M Schallhorn, MD

Researchers from Japan treated bullous keratopathy with an injection of cultured human corneal endothelial cells supplemented with a rho-associated protein kinase inhibitor.

Editors' Choice

Comments 0

Views 7631

DMEK rates on the rise in Germany

APR 06, 2018 By Wuqaas M Munir MD

This study retrospectively analyzed data from the German Keratoplasty Registry to delineate trends in corneal transplantation.

Editors' Choice

Comments 0

Views 262

Should physicians stratify CXL waiting time by age?

MAR 26, 2018 By Karolinne M Rocha MD

Investigators of this observational study examined topographical changes in patients with keratoconus while awaiting corneal crosslinking (CXL) treatment.

Editors' Choice

Comments 0

Views 607

Combining DMEK with cataract surgery may increase graft detachment risk

MAR 20, 2018 By Wuqaas M Munir MD

This retrospective analysis examined risk factors for early graft detachment in Descemet membrane endothelial keratoplasty (DMEK).

Editors' Choice

Comments 0

Views 462

Existing evidence suggests DMEK is safe, effective for endothelial failure

FEB 22, 2018 By Damien M Luviano MD

This assessment by the Ophthalmic Technology Assessment Committee of the Academy’s Cornea and Anterior Segment Disorders Panel reviews the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) to treat corneal endothelial dysfunction.

Editors' Choice

Comments 0

Views 406

Boston KPro implants appear unsafe for children

FEB 08, 2018 By Damien M Luviano MD

Researchers examined visual outcomes and complications of Boston type 1 keratoprosthesis (KPro) implants in a pediatric population.

Editors' Choice

Comments 0

Views 660

Scleral lenses reduce need for surgical intervention in severe keratoconus

FEB 06, 2018 By Wuqaas M Munir MD

This retrospective case series suggests that scleral contact lens correction may significantly reduce the rate of transplant surgery in patients with severe keratoconus.

Editors' Choice

Comments 0

Views 364

Accelerated, standard CXL protocols both effective for pediatric keratoconus

FEB 01, 2018 By Rahul T Pandit MD

This prospective study compared the safety and efficacy of accelerated transepithelial (A-epi-on) corneal collagen crosslinking (CXL) with standard epi-off CXL in children with progressive keratoconus.

Editors' Choice

Comments 0

Views 858

Epithelial erosions less common in myopic eyes treated with transepithelial vs. alcohol-assisted PRK

JAN 25, 2018 By Rahul T Pandit MD

This study compared the incidence of epithelial erosions 1 year after transepithelial photorefractive keratectomy (PRK) versus alcohol-assisted PRK.

Editors' Choice

Comments 0

Views 150

Dilute bleach best for disinfecting tonometry equipment

DEC 21, 2017 By Damien M Luviano MD

The latest Ophthalmic Technology Assessment explores the most effective method for disinfecting reusable tonometers.

Editors' Choice

Comments 0

Views 1326

Limbal stem cell transplantation appears suited for severe ocular surface disorders

DEC 14, 2017 By Wuqaas M Munir MD

This is the largest study to examine long-term outcomes following allogenic ocular surface stem cell transplantation for limbal stem cell deficiency.

Editors' Choice

Comments 0

Views 498

CXL effective for treating corneal ectasia after refractive surgery

NOV 06, 2017 By Damien M Luviano MD, Rahul T Pandit MD

This randomized sham-controlled trial evaluated the safety and efficacy of corneal crosslinking for patients who developed corneal ectasia after laser refractive surgery.

Editors' Choice

Comments 0

Views 1263

DSAEK linked to better long-term vision outcomes

OCT 11, 2017 By Wuqaas M Munir MD

This prospective study compared 5-year outcomes between Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) in Asian eyes.

Editors' Choice

Comments 0

Views 300

Topical IL-1 inhibitor for dry eye shows moderate early outcomes

SEP 28, 2017 By Michelle K Rhee MD

A phase 1b/2a clinical trial evaluated the safety and tolerability of isunakinra, a novel topical interleukin-1 receptor inhibitor, for treatment of the signs and symptoms of dry eye disease.

Editors' Choice

Comments 0

Views 141

High rate of no light perception in Boston KPro eyes

SEP 15, 2017 By Wuqaas M Munir MD

This retrospective, interventional case series reported the rate of no light perception following Boston Keratoprosthesis type 1 surgeries.

Editors' Choice

Comments 0

Views 69

Extended MMC application time may help prevent haze after PRK

AUG 28, 2017 By Rahul T Pandit MD

This single-center, retrospective study evaluated the incidence and risk factors for corneal breakthrough haze following photorefractive keratectomy (PRK) with mitomycin c (MMC).

Editors' Choice

Comments 0

Views 560

Large cohort confirms SMILE’s safety and excellent visual outcomes

AUG 22, 2017 By Zaina N Al-Mohtaseb MD

A review of over 3,000 cases finds low rates of serious or vision-impacting complications during small-incision lenticule extraction.

Editors' Choice

Comments 0

Views 563

Scientists zero in on key protein driving HSV-1 inflammation

JUL 24, 2017 By Damien M Luviano MD

Scientists from the University of Illinois at Chicago have identified the enzyme heparanase as the crucial factor involved in herpes simplex (HSV-1)-associated corneal inflammation.

Editors' Choice

Comments 0

Views 385

Central descemetorhexis without grafting can treat some Fuchs cases

JUL 18, 2017 By Julie M Schallhorn, MD

Investigators report the safety and efficacy of descemetorhexis without donor tissue as a primary treatment for Fuchs endothelial dystrophy.

Editors' Choice

Comments 0

Views 1068

Fusarium keratitis ulcers respond to additional oral voriconazole

JUN 28, 2017 By Renée Solomon, MD

This secondary analysis of the Mycotic Ulcer Treatment Trial (MUTT) II clinical trial explores the role of adjuvant oral voriconazole on clinical outcomes in Fusarium keratitis.

Editors' Choice

Comments 0

Views 135

New regenerating agent may facilitate post-CXL corneal healing

JUN 08, 2017 By Ronald Luke Rebenitsch, MD

This prospective, randomized, single-masked study assessed the ability of a new matrix therapy regenerating agent (RGTA) to speed corneal healing following epithelial-off corneal crosslinking (CXL).

Editors' Choice

Comments 0

Views 466

Transepithelial CXL offers promising early results, faster recovery

JUN 05, 2017 By Damien M Luviano MD

This head-to-head comparison found that corneal crosslinking (CXL) using either a transepithelial approach with iontophoresis (T-ionto CXL) or the standard Dresden protocol provides favorable visual outcomes in patients with progressive keratoconus.

Editors' Choice

Comments 0

Views 817

Confocal microscopy and OCT show agreement for measuring post-CXL demarcation line

MAY 18, 2017 By Wuqaas M Munir MD

This prospective case series investigated the utility of 3 imaging modalities for assessing the post-CXL demarcation line in vivo.

Editors' Choice

Comments 0

Views 203

Corneal cross-linking appears effective and safe after 7 years

MAY 08, 2017 By Wuqaas M Munir MD

This 7-year cohort study reports positive outcomes on the long-term effectiveness of corneal collagen cross-linking (CXL) to halt progression of keratoconus.

Editors' Choice

Comments 0

Views 58

Nationwide antibiotic resistance rates show 5-year stability

MAY 03, 2017 By Misha Faustina MD

Five-year results from the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) study.

Editors' Choice

Comments 0

Views 205

Thicker SMILE caps may suppress wound healing response

APR 17, 2017 By Rahul T Pandit MD

This prospective randomized trial compared cap thickness in small incision lenticule extraction (SMILE) in patients with thick corneas, and found that visual outcomes are similar for both thin and thick flaps, but a thicker cap conferred better corneal recovery.

Editors' Choice

Comments 0

Views 338

Lifitegrast (Xiidra) now FDA-approved for dry eye

FEB 08, 2017 By Anat Galor MD

Dr. Anat Galor discusses lifitegrast (Xiidra), and her approach to treating dry eye

Editors' Choice

Comments 0

Views 1212

Acyclovir significantly reduces HSV recurrence after pediatric PK

JAN 17, 2017 By Rahul Bhola MD

Children who undergo penetrating keratoplasty (PK) for herpes simplex virus (HSV) keratitis require long-term antiviral prophylaxis. This, according to the largest case series yet to evaluate the outcome of pediatric corneal transplantation.

Editors' Choice

Comments 0

Views 363

New hope for restoring vision to scarred corneas

NOV 11, 2016 By Charles C Lin MD

Scientists from Schepens Eye Research Institute have shown that mesenchymal stem cells restore corneal transparency by secreting high levels of hepatocyte growth factor.

Editors' Choice

Comments 0

Views 373

Epi-on CXL can treat advanced keratoconus

AUG 31, 2016 By Wuqaas M Munir MD

Investigators have shown that epithelium-on corneal collagen crosslinking (CXL) using tetracaine can result in significant corneal flattening and improved vision in patients with advanced kerataconus.

Editors' Choice

Comments 0

Views 1669

Blood-derived topical therapy for ocular surface diseases

JUL 27, 2016 By Charles C Lin MD

This literature review reveals that though the body of clinical data is small, autologous serum (ASE), allogenic serum, umbilical cord serum and platelet-derived plasma preparation eye drops have consistently shown positive results in treating dry eye disease and persistent…

Editors' Choice

Comments 0

Views 584

New method to manage post-cataract Descemet detachment

JUN 01, 2016 By Wuqaas M Munir MD

The authors describe a novel protocol for managing post-phacoemulsification Descemet membrane detachment.

Editors' Choice

Comments 0

Views 3042

Stem cells regrow human lens, corneal tissue

MAR 16, 2016 By Keng Jin Lee

Scientists have shown that human cells can be reprogrammed to grow sheets of corneal tissue, and that stem cells in the human eye can be coaxed to regrow clear lenses after cataract surgery.

Editors' Choice

Comments 0

Views 4218

Loteprednol prevents graft rejection with less IOP risk

FEB 10, 2016 By Jennifer Li, MD

As DMEK surgery slowly becomes more popular as a treatment for endothelial dysfunction, it is important to assess if it is possible to safely reduce the use of corticosteroids after surgery.

Editors' Choice

Comments 0

Views 328

Hybrid technique for pterygium surgery shows promise

JAN 19, 2016 By Charles Lin, MD

The authors describe a novel combination technique for pterygium excision that may be a better option in patients with limited amounts of conjunctiva.

Editors' Choice

Comments 0

Views 2309

Keratoplasty for keratoconus on the decline

DEC 21, 2015 By Jennifer Li, MD

This retrospective review shows that the introduction of corneal collagen crosslinking may have reduced the number of keratoplasty procedures for keratoconus.

Editors' Choice

Comments 0

Views 507

Fusarium keratitis more responsive to natamycin

DEC 02, 2015 By Charles Lin, MD

This study adds to the growing body of literature that suggests natamycin may be more effective for treating fungal keratitis than voriconazole.

Editors' Choice

Comments 0

Views 284

Ocular neuropathic pain linked to vitamin B12 deficiency

NOV 04, 2015 By Jennifer Li, MD

Case report brings to light a potentially under-diagnosed cause of ocular neuropathic pain – vitamin B12 deficiency.

Editors' Choice

Comments 0

Views 1252

Adjuvant CXL appears ineffective for recalcitrant fungal keratitis

JUL 21, 2015 By Anat Galor, MD

Combining corneal cross-linking (CXL) with topical anti-fungal drugs didn’t improve outcomes for recalcitrant deep stromal fungal keratitis in this randomized, controlled trial.

Editors' Choice

Comments 0

Views 286

Herpes zoster on the rise in younger adults

JUN 05, 2015 By Jennifer Li, MD

Since universal varicella vaccination for children began in 1996, more younger adults, especially females, are developing herpes zoster ophthalmicus (HZO) in the United States.

Editors' Choice

Comments 0

Views 660

Glaucoma a primary cause of vision loss following KPro implantation

APR 28, 2015 By Anat Galor, MD, MSPH

This retrospective study underscores the possibility of good, long-term visual outcomes following KPro implantation, even in patients with complicated ocular issues.

Editors' Choice

Comments 0

Views 81

Refractive surgery safe in some corneal dystrophies

APR 14, 2015 By Robert E. Fintelmann, MD, FACS

This comprehensive review of the latest research on refractive surgery provides guidance on which procedures may be performed with caution in patients with corneal dystrophies.

Editors' Choice

Comments 0

Views 398

Nicergoline shows promise in neurotrophic keratopathy

APR 01, 2015 By Jennifer Li, MD

This small study shows that oral nicergoline can help facilitate healing in patients with neurotrophic keratopathy.

Editors' Choice

Comments 0

Views 120

Chronic obstructive pulmonary disease a risk factor for corneal damage during cataract surgery

FEB 23, 2015 By Wuquaas M. Munir, MD

This prospective study found that patients with chronic obstructive pulmonary disease may be more likely to suffer corneal endothelial damage during intraocular surgery.

Editors' Choice

Comments 0

Views 735

Preservative-free drops better than preserved drops after cataract surgery

FEB 17, 2015 By Lisa B. Arbisser, MD

This randomized study found that the signs and symptoms of dry eye were significantly reduced after cataract surgery followed by the use of preservative-free sodium hyaluronate 0.1% and fluorometholone 0.1% eye drops compared with preserved drops.

Editors' Choice

Comments 0

Views 4056

AS-OCT can help diagnose CMV corneal endotheliitis

FEB 11, 2015 By Jennifer Li, MD

AS-OCT provided novel and detailed visual information of coin-shaped lesions in two patients with CMV corneal endotheliitis.

Editors' Choice

Comments 0

Views 72

Descemet stripping without donor graft not recommended

FEB 05, 2015 By Jennifer Li, MD

This small case series found that not using a donor graft after Descmet stripping can impede endothelial cell repopulation and lead to worse visual outcomes.

Editors' Choice

Comments 0

Views 120

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