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Editors' Choice

Each month, the ONE Editors review leading journals to bring you concise summaries of the most clinically significant studies recently published. Some selections also include commentary from the ONE Editors, recognized leaders in their subspecialty.

All Journal Studies section content represents the opinions of the contributing authors and does not imply endorsement by the American Academy of Ophthalmology.
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Cornea/External Disease
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1-50 of 364 results

Adjunctive oral voriconazole offers no benefit in treating fungal keratitis

AUG 16, 2018 By Wuqaas M Munir MD

Researchers assessed the efficacy of oral voriconazole for treating filamentous fungal keratitis.

Editors' Choice

Comments 0

Views 21

Rapid warming protocol cuts down on evaluation times for donor corneal tissue

AUG 01, 2018 By Jordan A Margo, MD

Investigators retrospectively assessed the effect of a rapid tissue warming protocol on tissue evaluation times and specular image quality.

Editors' Choice

Comments 0

Views 52

Standard Dresden protocol enhances outcomes for people with keratoconus

JUL 24, 2018 By Rahul T Pandit MD

This retrospective study compared the outcomes of patients who underwent either standard Dresden or accelerated corneal collagen cross-linking (CXL) for keratoconus.

Editors' Choice

Comments 0

Views 453

SMILE induces long-term reduction in posterior astigmatism

JUL 10, 2018 By Rahul T Pandit MD

This study describes the 3-year changes in anterior and posterior corneal irregular astigmatism and curvature after small incision lenticule extraction.

Editors' Choice

Comments 0

Views 578

High risk of depression in women reporting dry eye symptoms

JUL 09, 2018 By Wuqaas M Munir MD

This cross-sectional study explores whether ocular features of keratoconjunctivitis sicca (KCS) or symptoms of dry eye disease are associated with depression in women with Sjögren syndrome (SS).

Editors' Choice

Comments 0

Views 427

Do transportation protocols impact DMEK graft viability?

JUN 29, 2018 By Charles C Lin MD

This experimental study compared 2 techniques of preservation and transportation of Descemet membrane endothelial keratoplasty (DMEK) grafts.

Editors' Choice

Comments 0

Views 49

Predicting visual outcomes of patients who develop endophthalmitis after anti-VEGF injection

JUN 27, 2018 By Seenu Hariprasad MD

This paper describes the presentation and outcomes of patients who developed endophthalmitis after intravitreal injection with VEGF inhibitors.

Editors' Choice

Comments 0

Views 1464

CXL confers long-term stability of keratoconus in pediatric patients

JUN 21, 2018 By Rahul T Pandit MD

This prospective longitudinal study demonstrates the long-term ability of corneal crosslinking to slow keratoconus progression in pediatric patients.

Editors' Choice

Comments 0

Views 843

Timely management of vitreoretinal complications after osteo-odonto-keratoprosthesis surgery can preserve vision

JUN 07, 2018 By Damien M Luviano MD

In this retrospective case series, investigators analyzed vitreoretinal complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery.

Editors' Choice

Comments 0

Views 657

Low-dose steroids lose efficacy in patients with concurrent dry eye and GVHD

MAY 31, 2018 By Wuqaas M Munir MD

This study compares the efficacy of topical steroids in patients with dry eye disease (DED) who do or do not have underlying graft-vs-host disease (GVHD).

Editors' Choice

Comments 0

Views 439

Cataract, corneal surgeries most likely to result in ophthalmology malpractice claims

MAY 14, 2018 By Bryan S Lee, MD JD

This review of data from the Physician Insurers Association of America professional liability registry examined claims against ophthalmologists over a 10-year period.

Editors' Choice

Comments 0

Views 1048

Repeat cultures may guide treatment of severe fungal keratitis

MAY 10, 2018 By Wuqaas M Munir MD

This secondary analysis of the Mycotic Ulcer Treatment Trial II (MUTT II) found that patients with a positive 6-day fungal culture carry a high risk of corneal perforation.

Editors' Choice

Comments 0

Views 746

Riboflavin dosing intervals do not impact CXL outcomes

APR 27, 2018 By Rahul T Pandit MD

This prospective, randomized trial compared the effectiveness of 2 riboflavin dosing intervals for corneal crosslinking (CXL).

Editors' Choice

Comments 0

Views 636

Novel treatment restores corneal clarity in patients with bullous keratopathy

APR 17, 2018 By Julie M Schallhorn, MD

Researchers from Japan treated bullous keratopathy with an injection of cultured human corneal endothelial cells supplemented with a rho-associated protein kinase inhibitor.

Editors' Choice

Comments 0

Views 7916

DMEK rates on the rise in Germany

APR 06, 2018 By Wuqaas M Munir MD

This study retrospectively analyzed data from the German Keratoplasty Registry to delineate trends in corneal transplantation.

Editors' Choice

Comments 0

Views 318

Should physicians stratify CXL waiting time by age?

MAR 26, 2018 By Karolinne M Rocha MD

Investigators of this observational study examined topographical changes in patients with keratoconus while awaiting corneal crosslinking (CXL) treatment.

Editors' Choice

Comments 0

Views 648

Combining DMEK with cataract surgery may increase graft detachment risk

MAR 20, 2018 By Wuqaas M Munir MD

This retrospective analysis examined risk factors for early graft detachment in Descemet membrane endothelial keratoplasty (DMEK).

Editors' Choice

Comments 0

Views 532

Existing evidence suggests DMEK is safe, effective for endothelial failure

FEB 22, 2018 By Damien M Luviano MD

This assessment by the Ophthalmic Technology Assessment Committee of the Academy’s Cornea and Anterior Segment Disorders Panel reviews the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) to treat corneal endothelial dysfunction.

Editors' Choice

Comments 0

Views 425

Boston KPro implants appear unsafe for children

FEB 08, 2018 By Damien M Luviano MD

Researchers examined visual outcomes and complications of Boston type 1 keratoprosthesis (KPro) implants in a pediatric population.

Editors' Choice

Comments 0

Views 683

Scleral lenses reduce need for surgical intervention in severe keratoconus

FEB 06, 2018 By Wuqaas M Munir MD

This retrospective case series suggests that scleral contact lens correction may significantly reduce the rate of transplant surgery in patients with severe keratoconus.

Editors' Choice

Comments 0

Views 406

Accelerated, standard CXL protocols both effective for pediatric keratoconus

FEB 01, 2018 By Rahul T Pandit MD

This prospective study compared the safety and efficacy of accelerated transepithelial (A-epi-on) corneal collagen crosslinking (CXL) with standard epi-off CXL in children with progressive keratoconus.

Editors' Choice

Comments 0

Views 906

Epithelial erosions less common in myopic eyes treated with transepithelial vs. alcohol-assisted PRK

JAN 25, 2018 By Rahul T Pandit MD

This study compared the incidence of epithelial erosions 1 year after transepithelial photorefractive keratectomy (PRK) versus alcohol-assisted PRK.

Editors' Choice

Comments 0

Views 155

Dilute bleach best for disinfecting tonometry equipment

DEC 21, 2017 By Damien M Luviano MD

The latest Ophthalmic Technology Assessment explores the most effective method for disinfecting reusable tonometers.

Editors' Choice

Comments 0

Views 1422

Limbal stem cell transplantation appears suited for severe ocular surface disorders

DEC 14, 2017 By Wuqaas M Munir MD

This is the largest study to examine long-term outcomes following allogenic ocular surface stem cell transplantation for limbal stem cell deficiency.

Editors' Choice

Comments 0

Views 506

CXL effective for treating corneal ectasia after refractive surgery

NOV 06, 2017 By Damien M Luviano MD, Rahul T Pandit MD

This randomized sham-controlled trial evaluated the safety and efficacy of corneal crosslinking for patients who developed corneal ectasia after laser refractive surgery.

Editors' Choice

Comments 0

Views 1290

DSAEK linked to better long-term vision outcomes

OCT 11, 2017 By Wuqaas M Munir MD

This prospective study compared 5-year outcomes between Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) in Asian eyes.

Editors' Choice

Comments 0

Views 311

Topical IL-1 inhibitor for dry eye shows moderate early outcomes

SEP 28, 2017 By Michelle K Rhee MD

A phase 1b/2a clinical trial evaluated the safety and tolerability of isunakinra, a novel topical interleukin-1 receptor inhibitor, for treatment of the signs and symptoms of dry eye disease.

Editors' Choice

Comments 0

Views 147

High rate of no light perception in Boston KPro eyes

SEP 15, 2017 By Wuqaas M Munir MD

This retrospective, interventional case series reported the rate of no light perception following Boston Keratoprosthesis type 1 surgeries.

Editors' Choice

Comments 0

Views 74

Extended MMC application time may help prevent haze after PRK

AUG 28, 2017 By Rahul T Pandit MD

This single-center, retrospective study evaluated the incidence and risk factors for corneal breakthrough haze following photorefractive keratectomy (PRK) with mitomycin c (MMC).

Editors' Choice

Comments 0

Views 587

Large cohort confirms SMILE’s safety and excellent visual outcomes

AUG 22, 2017 By Zaina N Al-Mohtaseb MD

A review of over 3,000 cases finds low rates of serious or vision-impacting complications during small-incision lenticule extraction.

Editors' Choice

Comments 0

Views 589

Scientists zero in on key protein driving HSV-1 inflammation

JUL 24, 2017 By Damien M Luviano MD

Scientists from the University of Illinois at Chicago have identified the enzyme heparanase as the crucial factor involved in herpes simplex (HSV-1)-associated corneal inflammation.

Editors' Choice

Comments 0

Views 403

Central descemetorhexis without grafting can treat some Fuchs cases

JUL 18, 2017 By Julie M Schallhorn, MD

Investigators report the safety and efficacy of descemetorhexis without donor tissue as a primary treatment for Fuchs endothelial dystrophy.

Editors' Choice

Comments 0

Views 1224

Fusarium keratitis ulcers respond to additional oral voriconazole

JUN 28, 2017 By Renée Solomon, MD

This secondary analysis of the Mycotic Ulcer Treatment Trial (MUTT) II clinical trial explores the role of adjuvant oral voriconazole on clinical outcomes in Fusarium keratitis.

Editors' Choice

Comments 0

Views 139

New regenerating agent may facilitate post-CXL corneal healing

JUN 08, 2017 By Ronald Luke Rebenitsch, MD

This prospective, randomized, single-masked study assessed the ability of a new matrix therapy regenerating agent (RGTA) to speed corneal healing following epithelial-off corneal crosslinking (CXL).

Editors' Choice

Comments 0

Views 473

Transepithelial CXL offers promising early results, faster recovery

JUN 05, 2017 By Damien M Luviano MD

This head-to-head comparison found that corneal crosslinking (CXL) using either a transepithelial approach with iontophoresis (T-ionto CXL) or the standard Dresden protocol provides favorable visual outcomes in patients with progressive keratoconus.

Editors' Choice

Comments 0

Views 834

Confocal microscopy and OCT show agreement for measuring post-CXL demarcation line

MAY 18, 2017 By Wuqaas M Munir MD

This prospective case series investigated the utility of 3 imaging modalities for assessing the post-CXL demarcation line in vivo.

Editors' Choice

Comments 0

Views 207

Corneal cross-linking appears effective and safe after 7 years

MAY 08, 2017 By Wuqaas M Munir MD

This 7-year cohort study reports positive outcomes on the long-term effectiveness of corneal collagen cross-linking (CXL) to halt progression of keratoconus.

Editors' Choice

Comments 0

Views 88

Nationwide antibiotic resistance rates show 5-year stability

MAY 03, 2017 By Misha Faustina MD

Five-year results from the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) study.

Editors' Choice

Comments 0

Views 244

Thicker SMILE caps may suppress wound healing response

APR 17, 2017 By Rahul T Pandit MD

This prospective randomized trial compared cap thickness in small incision lenticule extraction (SMILE) in patients with thick corneas, and found that visual outcomes are similar for both thin and thick flaps, but a thicker cap conferred better corneal recovery.

Editors' Choice

Comments 0

Views 342

Lifitegrast (Xiidra) now FDA-approved for dry eye

FEB 08, 2017 By Anat Galor MD

Dr. Anat Galor discusses lifitegrast (Xiidra), and her approach to treating dry eye

Editors' Choice

Comments 0

Views 1270

Acyclovir significantly reduces HSV recurrence after pediatric PK

JAN 17, 2017 By Rahul Bhola MD

Children who undergo penetrating keratoplasty (PK) for herpes simplex virus (HSV) keratitis require long-term antiviral prophylaxis. This, according to the largest case series yet to evaluate the outcome of pediatric corneal transplantation.

Editors' Choice

Comments 0

Views 368

New hope for restoring vision to scarred corneas

NOV 11, 2016 By Charles C Lin MD

Scientists from Schepens Eye Research Institute have shown that mesenchymal stem cells restore corneal transparency by secreting high levels of hepatocyte growth factor.

Editors' Choice

Comments 0

Views 374

Epi-on CXL can treat advanced keratoconus

AUG 31, 2016 By Wuqaas M Munir MD

Investigators have shown that epithelium-on corneal collagen crosslinking (CXL) using tetracaine can result in significant corneal flattening and improved vision in patients with advanced kerataconus.

Editors' Choice

Comments 0

Views 1830

Blood-derived topical therapy for ocular surface diseases

JUL 27, 2016 By Charles C Lin MD

This literature review reveals that though the body of clinical data is small, autologous serum (ASE), allogenic serum, umbilical cord serum and platelet-derived plasma preparation eye drops have consistently shown positive results in treating dry eye disease and persistent…

Editors' Choice

Comments 0

Views 597

New method to manage post-cataract Descemet detachment

JUN 01, 2016 By Wuqaas M Munir MD

The authors describe a novel protocol for managing post-phacoemulsification Descemet membrane detachment.

Editors' Choice

Comments 0

Views 3080

Stem cells regrow human lens, corneal tissue

MAR 16, 2016 By Keng Jin Lee

Scientists have shown that human cells can be reprogrammed to grow sheets of corneal tissue, and that stem cells in the human eye can be coaxed to regrow clear lenses after cataract surgery.

Editors' Choice

Comments 0

Views 4340

Loteprednol prevents graft rejection with less IOP risk

FEB 10, 2016 By Jennifer Li, MD

As DMEK surgery slowly becomes more popular as a treatment for endothelial dysfunction, it is important to assess if it is possible to safely reduce the use of corticosteroids after surgery.

Editors' Choice

Comments 0

Views 328

Hybrid technique for pterygium surgery shows promise

JAN 19, 2016 By Charles Lin, MD

The authors describe a novel combination technique for pterygium excision that may be a better option in patients with limited amounts of conjunctiva.

Editors' Choice

Comments 0

Views 2318

Keratoplasty for keratoconus on the decline

DEC 21, 2015 By Jennifer Li, MD

This retrospective review shows that the introduction of corneal collagen crosslinking may have reduced the number of keratoplasty procedures for keratoconus.

Editors' Choice

Comments 0

Views 518

Fusarium keratitis more responsive to natamycin

DEC 02, 2015 By Charles Lin, MD

This study adds to the growing body of literature that suggests natamycin may be more effective for treating fungal keratitis than voriconazole.

Editors' Choice

Comments 0

Views 286

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