Bimatoprost and latanoprost appear similarly effective in patients with primary angle closure glaucoma

This observer-masked study randomized 54 patients (80 eyes) to receive latanoprost 0.005% or bimatoprost 0.03% for six weeks. Patients were then crossed over to the other medication for another six weeks without a washout period. IOP lowering effect was similar (8.4 mmHg with latanoprost vs. 8.9 mmHg with bimatoprost). Bimatoprost was slightly more effective in subjects with .3 clock hours of PAS and may be preferable in eyes with advanced synechial closure. However, the higher frequency of ocular side effects of bimatoprost, though well tolerated, may be a consideration in prostaglandin analogue choice.