• Retina/Vitreous, Uveitis

    Review of: Posterior segment ophthalmic manifestations in Ebola survivors, Sierra Leone

    Berry D, Bavinger J, Fernandes A, et al. Ophthalmology, in press

    This study describes the posterior segment manifestations of Ebola survivors in Sierra Leone.

    Study design

    This is a secondary analysis of 125 individuals (250 eyes) enrolled in the Ebola Virus Persistence in Ocular Tissues (EVICT) study. The study assessed the persistence of Ebola virus RNA in eyes prior to cataract surgery. Two-hundred and twenty eyes had sufficiently clear media for dilated funduscopic examination.


    Posterior segment abnormalities were found in 19.2% of eyes. The most common vitreoretinal finding was chorioretinal scarring, seen in 10% of eyes; 2.4% had retinal detachment. Eyes with posterior segment pathology had significantly worse visual acuity compared with eyes without posterior segment disease.


    This study was limited by the study design, the secondary analysis of a cross-sectional study, and selection bias. These patients were screened for enrollment into the EVCIT study and might represent a population of patients that had a vision problem, increasing the prevalence of our findings and introducing a bias for worse vision.

    Clinical significance

    Emerging infectious diseases continue to play a key role in our everyday lives. It is important to identify the spectrum of ophthalmic findings associated with these unique diseases so that practitioners can identify patients that may have active disease or sequalae from previous disease.