NOV 24, 2021
This retrospective, observational, series study looked for cases of actinic granuloma of the conjunctiva in patient records covering a 6-year period to discover its clinical manifestations and histopathologic features.
Institutional pathology records between 2014 and 2020 were searched for all cases of conjunctival actinic granuloma. Eight eyes of 8 patients were identified.
Histopathologically, actinic granuloma was associated with pterygium (n = 6, 75%) and pinguecula (n = 2, 25%). All lesions comprised predominantly histiocytes and a variable number of foreign body–type giant cells associated with a focus of severe actinic elastosis. The inflammatory pattern was giant cell (n = 4, 50%), sarcoidal (n = 2, 25%), histiocytic (n = 1, 13%), and combined histiocytic and sarcoidal (n = 1, 13%).
Conjunctival actinic granuloma has diverse clinical and histopathologic manifestations, which need to be distinguished from other autoimmune, neoplastic, and infectious etiologies. This lesion frequently occurs in pre-existing pterygium and pinguecula and may be associated with allergy and atopy.