JUN 08, 2018
Using OCT angiography, investigators measured the peripapillary perfused capillary density (PCD) in patients with myopia and open-angle glaucoma.
The study cohort was divided into the following groups:
- 87 patients with both myopia and glaucoma
- 17 myopic patients without glaucoma
- 93 glaucoma patients without myopia
Fifty-one healthy individuals served as controls. All participants were at least 20 years old with a BCVA 20/40 or greater. Myopia was defined as spherical equivalent of -3 D or more.
Researchers conducted a comprehensive ophthalmic examination and OCT angiography for each patient.
Average global PCD was significantly higher in the control group (41) than the myopia-only group (38), glaucoma-only group (31) or myopic-glaucoma group (28). Investigators found no associations between glaucoma and myopia after adjusting for age, axial length and disease stage.
Shortcomings include potential errors in capillary segmentation in eyes with high myopia. The number of subjects per treatment arm was small and patients were not well matched. The study lacked longitudinal data.
This is an important study demonstrating that structural OCT has limited value in evaluating patients with myopia. The findings show that functional capillary density could serve as a potential marker for glaucoma.