• Written By:
    Ocular Pathology/Oncology, Oculoplastics/Orbit

    This study evaluates the epidemiology, outcomes and prognostic factors of orbital lymphoma in the United States.

    Study design

    The authors searched a database to identify all cases of biopsy-proven orbital lymphoma from 1973 to 2014. They identified 1,504 cases and extracted demographic and histologic features.


    Mucosal associated lymphoid tissue (MALT) lymphomas were the most common (49.5%) and carried the best prognosis. Diffuse large B-cell lymphomas were the second most-common subtype (19.5%) and portended the worst outcomes. In addition to histologic subtype, the authors found that older age, male gender and the absence of radiation were tied to poor outcomes.


    The study reviews a large time frame and the statistics may have shifted as treatment options evolved. Furthermore, the study is retrospective in nature.

    Clinical significance

    The authors used a very large cohort of patients to explore a relatively uncommon entity. The results of this study may help to inform patients of their prognoses, based on their histologic and demographic features.