Inflammation after Avastin injection marked by early, painless visual acuity loss

This retrospective review of 2,500 consecutive Avastin injections performed at a single center revealed eight cases of post-injection inflammation. All eight patients had a marked anterior chamber reaction with increased flare and cells, but no hypopyon. Onset was within two days of injection. Most exhibited a typical "pseudogranulomatous" vitreous inflammation, but microbiological findings were negative.  Patients responded to systemic or topical cortisone treatment, but recovery was slow. No permanent retinal damage was observed.