OCT appears a good, noninvasive substitute for fluorescein angiography

Researchers examined 124 eyes (63 patients) with diabetic retinopathy and 23 control eyes with fluorescein angiography (FA) and high-speed Fourier-domain optical coherence tomography (OCT). Among the 62 eyes with diabetic retinopathy and FA evidence of either foveal avascular zone (FAZ) damage higher than grade 1 or FAZ capillary loss, OCT detected damage with a positive predictive value of 84.5 percent and negative predictive value of 72.9 percent. Damage locations seen on FA corresponded well with foveal ganglion cell layer damage on OCT. In control eyes, foveola size on OCT matched FAZ size on FA.