• Glaucoma

    This prospective study found that the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer are thinner (mGCIPL) in eyes with Sjogren syndrome, and that the degree of thinning correlates with increased numbers of positive autoantibody.

    To the authors’ knowledge, this is the first study to evaluate the relationship between autoantibody profiles and retinal morphological changes using spectral-domain OCT.

    Subjects were 196 patients (196 eyes) with primary Sjogren syndrome and 200 age- and sex-matched normal controls.The pRNFL and mGCIPL thicknesses of the Sjogren patients were thinner than that of the controls. These differences were most prominent in the average, inferior and temporal pRNFL thicknesses and minimum, superotemporal, inferotemporal, inferior and inferonasal mGCIPL thicknesses.

    There were no significant differences in optic nerve head parameters between Sjogren patients and normal controls. However, they did find a significant negative correlation among the number of positive autoantibodies and several parameters of pRNFL and mGCIPL.

    They conclude that although the patients in this study were not clinically regarded as having glaucomatous optic neuropathy, the findings suggest that Sjogren patients, especially those with increased positivity of autoantibodies, might be prone to developing glaucoma when exposed to other glaucomatous risk factors, such as increased IOP or vascular dysregulation. These findings should be considered when diagnosing or evaluating glaucomatous structural changes in patients with Sjogren syndrome.

    They say that a longitudinal follow-up study is needed to further elucidate the role of autoantibodies in retinal morphological changes and to determine whether these changes remain stable or show progression in a cohort of Sjogren patients.