MAR 01, 2015
This prospective, case-control study found a novel and strong association between the rs2165241 polymorphism in the LOXL1 gene and a high risk of primary open-angle glaucoma (POAG) in a Mediterranean population.
Subjects included 329 patients with POAG and 329 healthy controls matched by sex, all from Valencia, Spain and with the same ethnic characteristics.
Using a recessive genetic model, the authors found that the T allele of the rs2165241 polymorphism was significantly associated with the risk of POAG (odds ratio = 2.19). After adjustments for age and weight in a multivariate logistic regression model, the magnitude of the association decreased but remained statistically significant (odds ratio = 2.07).
They conclude that because this is the first report identifying this association, more research is required to replicate these results in populations with similar characteristics.