• This study conducted in rats demonstrated that topically applied trans-reservatrol reduces IOP in steroid-induced ocular hypertension.

    Trans-reservatrol is a natural polyphenol found in plants, such as grapes, wine, peanuts and pines.

    The authors studied unilateral single-drop application of various concentrations of trans-resveratrol in rats with steroid-induced ocular hypertension and rats that were oculonormotensive. They also observed the alterations of IOP in response to trans-resveratrol after pretreating rats with adenosine receptor subtype-specific antagonists.

    All concentrations of trans-resveratrol produced significant IOP reduction in normotensive rat eyes. A maximum mean IOP reduction of 15.1% was achieved with trans-resveratrol 0.2%. In oculohypertensive rats, trans-resveratrol 0.2% produced a peak IOP reduction of 25.2%.

    They say these results indicate that topical trans-resveratrol seems to have significant potential in reducing IOP not only in steroid-induced oculohypertension but also in primary open-angle glaucoma eyes. However, this needs to be confirmed in studies conducted in people.