Pythium insidiosum is an oomycete that closely mimics fungus in its morphological features. It belongs to the genus of parasitic oomycetes. Until recently, infection was managed with antifungals and early surgical intervention, which led to the loss of many eyes due to rapid worsening or higher chances of recurrence of infection on the graft. With increasing understanding of its cell wall structure, improvement in the clinical and microbiological diagnosis, in vitro susceptibility data, and in-house development of a rabbit Pythium keratitis model, the presenters developed a strategic medical and surgical approach to this deadly organism. This video highlights the steps of developing this approach. The unique and differentiating microscopic and clinical features of the infection are detailed to help all understand its natural course and a way to eradicate it.

Financial Disclosures: Drs. Savitri Sharma, Bhupesh Bagga, Joveeta Joseph, Pratima Rajendra Vishwakarma, and alit Kishore Ahirwar disclose no financial relationships.