2020–2021 BCSC Basic and Clinical Science Course™
11 Lens and Cataract
Chapter 5: Pathology
Metabolic Cataract
Wilson Disease
Wilson disease (hepatolenticular degeneration) is an inherited autosomal recessive disorder of copper metabolism. The characteristic ocular manifestation of Wilson disease is the Kayser-Fleischer ring, a golden-brown discoloration of Descemet membrane around the periphery of the cornea (Fig 5-21A). In addition, a characteristic sunflower cataract often develops. Reddish-brown pigment (cuprous oxide) is deposited in the anterior lens capsule and subcapsular cortex in a stellate shape that resembles the petals of a sunflower (Fig 5-21B). In most cases, the sunflower cataract does not cause serious visual impairment. See also BCSC Section 8, External Disease and Cornea.
Excerpted from BCSC 2020-2021 series: Section 11 - Lens and Cataract. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.