2020–2021 BCSC Basic and Clinical Science Course™
12 Retina and Vitreous
Part II: Disorders of the Retina and Vitreous
Chapter 08: Retinopathy of Prematurity
After each evaluation, the follow-up interval should be determined based on the disease features; more severe disease indicates a need for shorter follow-up intervals.
1-Week or Less Follow-up
immature vascularization: zone I—no ROP
immature retina extends into posterior zone II, near the boundary of zone I
stage 1 or 2 ROP: zone I
stage 3 ROP: zone II
the presence or suspected presence of aggressive posterior ROP
1- to 2-Week Follow-up
2- to 3-Week Follow-up
Retinal screening examinations can usually be discontinued when any one of the following criteria is met:
zone III retinal vascularization attained without previous zone I or II ROP (if there is examiner doubt about the zone or if the postmenstrual age is less than 35 weeks, confirmatory examinations may be warranted);
full retinal vascularization in close proximity to the ora serrata for 360°—that is, the normal distance found in mature retina between the end of vascularization and the ora serrata. This criterion should be used for all cases treated for ROP solely with bevacizumab;
postmenstrual age of 50 weeks and no prethreshold disease or more severe ROP is present; or
regression of ROP (care must be taken to ensure that there is no abnormal vascular tissue present that is capable of reactivation and progression in zone II or III).
Table 8-3 Definitions of Clinically Significant Retinopathy of Prematurity (CSROP) and ROP Requiring Treatment
Excerpted from BCSC 2020-2021 series: Section 10 - Glaucoma. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.