JUL 24, 2008
Comprehensive Ophthalmology, Uveitis
Introduction
Ocular toxoplasmosis is caused by the parasite Toxoplasma gondii. The organism may lead to acute or chronic infection in humans. Humans may acquire the disease by ingestion of the cyst of the parasite in undercooked beef, lamb, pork, or chicken. Other modes of transmission include the ingestion or inhalation of oocysts, by organ transplantation from infected donors, or by transplacental transmission. The systemic illness presents as a flu-like illness with fever, postauricular lymphadenopathy, myalgia, and malaise. Following acute systemic illness, the retina and choroid may become infected by the parasite several weeks to several years after the initial systemic illness.
The most common ocular manifestation is toxoplasmic retinochoroiditis.1 The inner layers of the retina are commonly involved, leading to a focus of necrotizing retinitis with subjacent choroiditis and cells in the vitreous. Retinal vasculitis is common in patients with ocular toxoplasmosis. The lesion may remain active for several weeks, undergoes healing, and forms a pigmented scar in the retina, which may be punched out.1 The retinochoroiditic scar of toxoplasma may harbor the toxoplasma cyst, and the organism may stay viable in the tissue for many years. Rupture of the cyst may lead to the release of toxoplasma organisms and recurrence of retinochoroiditis. Most of the recurrences occur in the second and third decades of life in immunocompetent individuals, and may be triggered by stress or other factors. In immunocompromised patients, eg, patients with AIDS, toxoplasmic retinochoroiditis may be severe, leading to wide destruction of the retina and choroid.
Therapy
The major objectives of therapy of toxoplasmosis include:
- Alleviate the symptoms and signs
- Control the infectious process
- Prevent damage by the inflammatory process
- Prevent recurrences
- Rehabilitate the vision
Treatment of acute toxoplasmic retinochoroiditis consists of 2 parts:
- Treat the acute disease process
- Manage the sequelae and the complications of ocular toxoplasmosis such as vitreous opacities, cataract, glaucoma, and choroidal neovascular membranes
Alleviation of Symptoms and Signs
Patients with ocular toxoplasmosis may present with history of blurring of vision and seeing floaters. In addition, patients may complain of redness and pain. The anterior uveitis may be treated with topical prednisolone acetate 1% eyedrops 4 times daily. Secondary glaucoma is treated with beta blockers such as timolol maleate 0.5% eyedrops twice daily. In some cases, patients may require the addition of carbonic anhydrase inhibitors topically or systemically. Patients with significant fibrin in the anterior chamber may need short-acting cycloplegic/ mydriatic such as cyclopentolate 1.0% eyedrops once every 12 hours.
Control of the Ocular Infection
Antimicrobial agents that are used for the inhibition of the tachyzoites of the T. gondii have limited effects against the encysted form of the parasite. Single-drug antimicrobial therapy is not sufficient for the treatment of toxoplasmosis. It is therefore conceded that antimicrobial agents should be combined in the management of toxoplasmosis2-4 (Figure 1 and Figure 2). The antitoxoplasma regimens that are used for the treatment of ocular toxoplasmosis are shown in Table 1.