• News in Review

    Careful Rx May Limit the Problem

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    Antibiotic resistance to common ocular pathogens continues to be a challenge, according to the most recent data from the ongoing Antibiotic Resis­tance Monitoring in Ocular Microor­ganisms (ARMOR) Surveillance Study, presented at the 2016 Association for Research in Vision and Ophthalmology (ARVO) annual meeting.1

    New data, continuing trends. The updated data are based on 441 isolates collected from 19 sites in 2015. The current findings follow a trend that has been observed since 2009, when the nationwide multicenter survey began looking at resistance of common ocular pathogens to several commonly used antibiotics. The data show high levels of antibiotic resistance among staphylococcal isolates, especially among methicillin-resistant (MR) strains, with many isolates demonstrating multidrug resistance.

    “This trend is here to stay; and even if it does not increase, the level is so high that not dealing with antibiotic resistance is not an option,” said Penny A. Asbell, MD, MBA, professor, Depart­ment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York.

    Key findings. The report analyzed organisms frequently implicated in bac­terial eye infections; common ocular isolates submitted by labs nationwide include Staphylococcus aureus (SA), co­agulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Haemophilus influenzae, and Pseudomonas aerugino­sa. The isolates were tested for suscep­tibility to as many as 15 antibiotics. Following are some of the key findings:

    • Resistance among staphylococci was most notable for azithromycin (54%-59%), oxacillin/methicillin (24%-45%), and ciprofloxacin (22%-28%).
    • CoNS isolates exhibited substantial levels of resistance to trimethoprim (26%) and tobramycin (19%).
    • 39% of CoNS isolates and 20% of SA isolates were resistant to 3 or more drug classes.
    • Multidrug resistance remained prevalent among MRSA (67%) and MRCoNS isolates (74%).
    • Resistance among P. aeruginosa iso­lates continues to be low, and H. influ­enzae isolates were generally susceptible to all antibiotics tested.

    Advice for clinicians. “Choosing the best antibiotic to use is not trivial,” said Dr. Asbell. It requires determining the possible organism and its sensitivities and the antibiotic’s ability to penetrate the target tissue, as well as its biocom­patibility or safety profile, she said.

    Dr. Asbell advised clinicians to keep handy the tables from the 5-year ARMOR surveillance study, including more than 3,200 isolates, published last year in JAMA Ophthalmology.2 “The ARMOR data can be useful for select­ing your first antibiotic to use, especial­ly if fortified compounded antibiotics are not available,” she said. “These data should be used hand-in-hand with lo­cal antibiograms from hospitals to aid therapy selection and improve antibiot­ic stewardship.”

    Dr. Asbell offered further recom­mendations for prescribing antibiotics:

    • Don’t prolong treatment.
    • Don’t use antibiotics to treat allergies and/or viral infections.
    • Consider antibiotic cycling/rotation based on resistance trend data.
    • Emphasize the importance of treat­ment adherence to your patients.

    ARMOR is continuing to collect ocular isolates from centers nationwide. In the meantime, Dr. Asbell urged clini­cians to “choose the antibiotic wisely” for the initial treatment, since not all antibiotics will work on all isolates. Then check culture results to adjust as the clinical course demands. “Clinical assessment still counts,” she said. “Each case needs to be considered individually.”

    —Miriam Karmel

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    1 Sanfilippo CM et al. Antibiotic Resistance Profiles of Ocular Pathogens—An Update from the 2015 ARMOR Surveillance Study. Poster presented at: ARVO Annual Meeting; May 4, 2016; Seattle.

    2 Asbell PA et al. JAMA Ophthalmol. 2015;133(12):1445-1454.

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    Relevant financial disclosures—Dr. Asbell: Bausch + Lomb: C (unrelated to this article).

    For full disclosures and disclosure key, see below.

    July 2016 News in Review Full Financial Disclosures

     

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