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  • Clinical Update

    Ocular Trauma and Guns: The Need for Data

    By Lori Baker-Schena, MBA, EdD, Contributing Writer, interviewing Alexander M. Garrett, MD, Gary N. Holland, MD, Pradeep S. Prasad, MD, MBA, Prem S. Subramanian, MD, PhD, Joseph T. Wertz, AB, and Albert Y. Wu, MD, PhD

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    In 2011, fresh from his oculofacial and orbital surgery fellowship at the University of Toronto, Albert Y. Wu, MD, PhD, came face-to-face with firearm-related ocular trauma in a New York City emergency department (ED).

    An American man had arranged for a Russian bride to travel to the United States with her daughter. As soon as the wife received her U.S. citizenship, she divorced the husband. “He went off the deep end” and shot them in the head, Dr. Wu recalled. And while both survived, he said, “their eyes and optic nerves were obliterated. The impact shattered their eyes. They ended up with a quality of life no one would want.”

    That night was the impetus for his research into gun violence and ocular trauma, said Dr. Wu, now at Stanford University in Palo Alto, California. Yet throughout the last decade, this has proved easier said than done.

    Less Lethal
    LESS LETHAL? This patient’s injuries, from a kinetic impact projectile, necessitated enucleation. “Less-lethal weapons resulting in ophthalmic injuries: A review and recent example of eye trauma,” by Cristos Ifantides, Galia A. Dietz, Karen L. Christopher, Taylor J. Slingsby, and Prem S. Subramanian. Ophthalmol Ther. 2020;9(3):1-7. CC BY-NC 4.0 International License.

    Research Roadblocks

    Inadequate funding. As Dr. Wu quickly found, no NIH grant support was avail­able, due to funding restrictions.

    The lack of federal funding can be partly attributed to legislation, notably what is known as the Dickey Amend­ment.1 Although the amendment—which was passed in 1996—explicitly halted funding only for studies that advocate and promote gun control, it was widely interpreted as blocking all studies of gun-related violence.2

    This funding freeze began to thaw when the FY2020 federal omnibus ap­propriations bill was signed into law on Dec. 20, 2019. With the bill’s passage, $25 million was designated for research on preventing deaths and injuries from guns, split equally between the NIH and the CDC.3

    No registry specific to eye injuries. Between 1988 and 2003, the United States Eye Injury Registry collected data on 11,360 eye trauma cases of all kinds.4 But as Chen et al. recently noted in Ophthalmology, the registry—established by the American Society of Ocu­lar Trauma—shut down in 2013.5

    Although other national trauma databases exist, they typically lack detailed information on ocular find­ings, including those from a patient’s intake examination in the ED. Chen et al. called for reestablishment of an independent eye trauma registry and pointed out that such a registry would help clinicians and researchers identify “superior evidence-based treatments” and provide better prognostic informa­tion to patients.5

    Training the Next Generation of Physicians

    Also at UCLA, Joseph T. Wertz, AB, a medical student, is leading an effort to bring firearm safety counseling into the medical school curriculum. He and four of his cohorts are building, implementing, and evaluating the efficacy of a mod­ule on firearm epidemiology and safety for first-year medical students.

    “We want to educate future physicians on how to have a conversation with patients about their individual risk for firearm injury, and we want to empower them to work with patients to lower this risk,” Mr. Wertz said. “An important component of our module will be the use of patient actors, who will make it possible for the medical students to prac­tice their counseling [skills].”

    Mr. Wertz added, “Physicians are in a unique position to counsel patients on firearm safety and, ideally, to help modi­fy their risk for firearm-related morbidity and mortality. They really need to seize the opportunity.”

    Studies on Ocular Outcomes

    Despite these challenges, researchers have conducted several studies in the last few years.

    A 16-year overview. In 2018, Dr. Wu and his colleagues published a study on the visual outcomes of patients who survived gunshot wounds to the head and were treated at two New York City hospitals during a 16-year period.6

    The researchers identified 915 affect­ed patients. Of these, 27 (3%) sustained ocular injuries, including orbital fracture, ruptured globe, foreign body, or optic nerve injury. Of the 22 patients whose records were available, 18 sur­vived, and eight of these 18 patients (44%) suffered permanent visual loss in at least one eye to the level of counting figures or worse. “We also found that almost half of the patients with ocular involvement had to have at least one eye removed,” Dr. Wu said.

    He added that the study supports the need to create a comprehensive da­tabank on firearms-related injuries, and noted, “We still have so many questions to answer, including demographic-based differences in gun trauma treat­ment, access to ophthalmologists in the ED, and the best treatment protocols for specific wounds.”

    The impact on children. In 2019, Weiss et al. evaluated the pattern of firearm-related ocular injuries in young people. They found that more than half of the injuries were associated with traumatic brain injury, and 12.2% of the injuries resulted in death.7

    For this study, the researchers used data from the National Trauma Data Bank. Of 8,715 firearm-related inju­ries leading to hospitalization during the study period (2008-2014), 1,972 (22.6%) were in people younger than 21 years of age (mean age 15.2 years).

    The most common ocular injuries were open wound of the eye (41.6%) or ocular adnexa (25.5%), orbital injury or fracture (30%), and contusion of the eye or adnexa (21.1%).

    The question of “less-lethal” pro­jectiles. Based on their experience with treating patients injured during last year’s racial justice protests in Denver, Prem S. Subramanian, MD, PhD, and his colleagues published a case report8 and a subsequent case series and nation­al survey of academic ophthalmology programs9 highlighting eye trauma caused by rubber bullets and other kinetic impact projectiles.

    In the case report, the patient had a severely ruptured globe with fractures involving the superior, inferior, medial, and lateral orbital walls, along with extensive hemorrhage and extrusion of intraocular contents. After several hours of surgery, the globe was closed anteriorly but had a massive posterior rupture, and the patient underwent enucleation three days later, said Dr. Subramanian, at the University of Colorado in Aurora.

    In their larger study, Dr. Subrama­nian and his research team reported five other individuals with eye injuries from “less-lethal” projectiles, one of whom was blinded in one eye. They also presented data showing that 20% of academic ophthalmology depart­ments responding to their survey—of note, 71% of all programs responded—treated patients with injuries, including open globes, that were sustained during the 2020 protests.

    Further Reading

    Lester EG et al. Emotional recovery after ocular trauma: Is there more than meets the eye? Eye (Lond). Published online Jan. 9, 2021.

    Hoskin AK et al. Eye injury registries—a systematic review. Injury. 2019;50(11):1839-1846.

    Iftikhar M et al. Characteristics of orbital floor fractures in the United States from 2006 to 2017. Ophthalmology. Pub­lished online July 10, 2020.

    Khalaily S et al. Airsoft gun-related ocular injuries: Long-term follow-up. J AAPOS. 2018;22(2):107-109.

    Moysidis SN et al. TASER injuries to the eye and ocular adnexa: The management of complex trauma. Ophthalmol Retina. 2019;3(3):258-269.

    Uppuluri A et al. Orbital floor fractures concurrent with acute open-globe injuries. Ophthalmology. Published online July 28, 2020.

    Studying the Survivors

    Gary N. Holland, MD, at the University of California, Los Angeles (UCLA), has had a longstanding interest in the impact of gun violence upon survivors. “I have treated patients with gunshot trauma to the eyes, and I recognize what a profound effect these injuries have on their lives.”

    Quantifying morbidity. Dr. Holland recruited Alexander M. Garrett, MD, a third-year emergency medicine resident at UCLA, to work alongside Pradeep S. Prasad, MD, MBA, to initiate a research program on patients treated at Harbor-UCLA Medical Center. A focus of the research, led by Dr. Prasad, is the long-term outcomes of gun-related injuries, including quality of life assessments.

    “While there has been an emphasis on mortality related to these injuries, there has been less focus on the public health aspects and individual health outcomes of patients [who survive],” Dr. Garrett said. “It is important to continue studying mortality, but we need to build up the knowledge base on morbidity.”

    In an initial quality assessment review, the UCLA team has gathered information including the extent of the injuries at presentation, the procedures that were performed, and, when avail­able, long-term outcomes—all aimed at improving a team approach to the management of these injuries.

    Dr. Prasad observed that the work has been challenging because of the lack of standardization in terms of data capture and documentation. “However,” he said, “this is an important first step in terms of our understanding and research planning.”

    To date, the team has found that its ocular trauma patients are overwhelm­ingly young—under age 30, Dr. Prasad said. The injuries themselves can be categorized into either orbital fractures or injuries to the globe, with some patients experiencing both, Dr. Garrett noted.

    Describing these outcomes pro­vides an opportunity to identify better surgical interventions for patients, Dr. Prasad said. “It is vital to understand both the causes of gun violence injuries and the disease burden. We can’t make data-driven decisions without the data.”


    1 Omnibus Consolidated Appropriations Act, Pub. L. No. 104-208 (1996). Accessed Jan. 14, 2021.

    2 Rostron A. Am J Public Health. 2018;108(7):865-867.

    3 Subbaraman N. Nature. 2020;577(7788):12.

    4 Kuhn F et al. Ophthalmic Epidemiol. 2006;13(3):209-216.

    5 Chen A et al. Ophthalmology. Published online Dec. 30, 2020.

    6 Chopra N et al. Eye (Lond). 2018;32:687-692.

    7 Weiss R et al. JAMA Ophthalmol. 2019;137(12):1363-1370.

    8 Ifantides C et al. Ophthalmol Ther. 2020;9(3):1-7.

    9 Ifantides C et al. JAMA Ophthalmol. Published online Dec. 3, 2020.


    Dr. Garrett is a third-year emergency medicine resident at Harbor-UCLA Medical Center in Los Angeles. Relevant financial disclosures: None.

    Dr. Holland is professor of ophthalmology, the Jack H. Skirball Chair in Ocular Inflammatory Diseases, and director of the Department of Oph­thalmology Clinical Research Center at UCLA’s David Geffen School of Medicine. He also is a member of the UCLA Stein Eye Institute. Rele­vant financial disclosures: University of California Firearm Violence Research Center: S.

    Dr. Prasad is chief of the Division of Ophthal­mology at Harbor-UCLA Medical Center in Los Angeles. He is also associate clinical professor of ophthalmology at the UCLA Stein Eye Institute. Relevant financial disclosures: None.

    Dr. Subramanian is professor of ophthalmology, neurology, and neurosurgery, director of neuro-ophthalmology, and vice chair for Academic Affairs at the University of Colorado School of Medicine in Aurora, Colo. Relevant financial disclosures: None.

    Mr. Wertz is a second-year medical student at UCLA’s David Geffen School of Medicine. Rele­vant financial disclosures: None.

    Dr. Wu is assistant professor of ophthalmology at the Stanford University Medical Center and director of Oculoplastics Research at the Stanford School of Medicine in Palo Alto, Calif. Relevant financial disclosures: None.

    For full disclosures and the disclosure key, see below.

    Full Financial Disclosures

    Dr. Garrett None.

    Dr. Holland Childhood Arthritis and Rheumatology Research Alliance: S; NEI: S; University of California Firearm Violence Research Center: S.

    Dr. Prasad Alimera Sciences: C; Allergan: S.

    Dr. Subramanian GenSight Biologics: C,S; Horizon Therapeutics: C,S; Invex Therapeutics: C; Santhera Pharmaceuticals: S.

    Mr. Wertz None.

    Dr. Wu None.

    Disclosure Category



    Consultant/Advisor C Consultant fee, paid advisory boards, or fees for attending a meeting.
    Employee E Employed by a commercial company.
    Speakers bureau L Lecture fees or honoraria, travel fees or reimbursements when speaking at the invitation of a commercial company.
    Equity owner O Equity ownership/stock options in publicly or privately traded firms, excluding mutual funds.
    Patents/Royalty P Patents and/or royalties for intellectual property.
    Grant support S Grant support or other financial support to the investigator from all sources, including research support from government agencies (e.g., NIH), foundations, device manufacturers, and/or pharmaceutical companies.