OHTS: 20 Years of Follow-up Data on POAG
By Jean Shaw
Selected and Reviewed By: Neil M. Bressler, MD, and Deputy Editors
JAMA Ophthalmology, May 2021
Kass et al. set out to determine the cumulative incidence and severity of primary open-angle glaucoma (POAG) during 20 years of follow-up among participants of the Ocular Hypertension Treatment Study (OHTS). They found that 25% of the study participants developed visual field loss during follow-up.
OHTS originally ran from February 1994 to December 2008. Follow-up began on Jan. 6, 2016, and it continued until April 15, 2019. During that time, study participants received ophthalmic examinations and visual function assessments.
Initially, 1,636 patients enrolled in OHTS. Their mean age was 55.4 years, 56.9% were women, and most were White (69.6%). Over the course of the study (including follow-up), 515 participants died. After a median follow-up of 20.2 years, 483 participants (29.5%) developed POAG in one or both eyes. The cumulative incidence of POAG at 20 years, adjusted for exposure time, was 45.6% among all participants. The cumulative incidence by ethnicity was 55.2% among Black participants and 42.7% among other ethnic groups. The 20-year cumulative incidence of visual field loss was 25.2%. When the OHTS prediction model—which categorizes patients into low-, medium-, and high-risk groups—was applied, the cumulative incidence of POAG was 31.7% among low-risk patients, versus 47.6% and 59.8% among those at medium and high risk, respectively.
The researchers noted that this information, when used with the OHTS prediction model, may help clinicians and patients make informed, personalized decisions about management of ocular hypertension.
The original article can be found here.