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  • Patching Retinal Breaks With Seprafilm for Treating Retinal Detachments

    By Marianne Doran and selected by Deepak P. Edward, MD

    Journal Highlights

    Published online Jan. 27, 2017

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    Haruta et al. described the long-term surgical outcomes of 4 patients who were treated for retinal detachment with the novel technique of using Seprafilm Adhesion Barrier (Sanofi). This material is a bioresorbable translu­cent membrane that was developed to prevent adhesions after abdominal and pelvic surgeries. At 9 years postsurgery, the researchers found that the retina remained attached in all 4 patients.

    The 4 patients (4 eyes) in this series had rhegmatogenous retinal detach­ment (RRD). The retinal breaks in these eyes were covered with Seprafilm, which was applied through a transvitre­al approach after cataract surgery, pars plana vitrectomy, fluid-air exchange, and laser photocoagulation. Neither long-lasting gas nor silicone oil was used. The patients were not instructed to maintain a specific head position postoperatively.

    The surgeons achieved successful retinal reattachment in all 4 eyes after a single procedure, and none of the patients developed proliferative vitre­oretinopathy, a major cause of surgical failure. All eyes had a transient post­operative intraocular pressure spike, which was managed with medication and resolved within 2 weeks. The Seprafilm was undetectable on fundus examination 2 weeks after surgery. The mean best-corrected visual acuities among these patients were 20/97 pre­operatively and 20/33 at 9 years after surgery. Further, the visual outcomes showed no apparent adverse effects related to the use of Seprafilm.

    The authors concluded that covering retinal breaks with Seprafilm may pro­mote retinal reattachment without the need for gas tamponade or postopera­tive head positioning. They commented that their work provides a basis for fur­ther clinical studies of retinal patching surgery in patients with RRDs.

    The original article can be found here.