• Subfoveal Choroidal Thickness as a Predictor for CSC

    By Peggy Denny and edited by Deepak P. Edward, MD

    Journal Highlights

    Published online Sept. 30, 2016

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    Central serous chorioretinopathy (CSC) remains poorly understood, despite its high prevalence. Ambiya et al. analyzed data from enhanced depth imaging optical coherence tomography (EDI-OCT) to evaluate the role of sub­foveal choroidal thickness (CT) in the course of the disease. They found that a thinner CT (<356 μm) was more likely to indicate chronic disease requiring treatment.

    In this retrospective chart review, the authors analyzed 38 treatment-naïve eyes of 33 patients (26 men, 7 women; mean age of 44.3 ± 8.8 years). Ocular history, demographics, laterality, and comorbidities were recorded; clinical examination included visual acuity, slit-lamp biomicroscopy, ophthalmoscopy, and—at the discretion of the investi­gator—digital fluorescein angiography with or without indocyanine green angiography. All eyes were examined with OCT, and EDI-OCT was used to measure subfoveal CT. Univariate and multivariate analyses for association of baseline features with need for treat­ment were performed.

    On multivariate regression analysis, the authors found that only baseline subfoveal CT had a statistically sig­nificant association with the need for treatment. Specifically, the mean baseline subfoveal CT was significantly lower (307.07 μm) in eyes that required treatment with laser photocoagula­tion, photodynamic therapy, or both, compared with eyes that were managed with observation (420.48 μm). Based on their analyses, the authors hypothe­sized that 356 μm was a possible critical CT value for deciding whether to treat or observe; and they classified eyes with CT <356 μm as Group A and those with CT >356 μm as Group B.

    The authors concluded that eyes in Group A were more likely to have chronic CSC that required treatment (12 of 22 eyes; 54.55%) compared with those in Group B (3 of 16 eyes; 18.75%). They also commented that EDI-OCT is an important tool for monitoring the course of CSC.

    The original article can be found here.