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    Toxoplasma Chorioretinitis

    Written By: Patrick R. Oellers, MD, Massachusetts Eye and Ear, Harvard Medical School, Boston; and Prithvi Mruthyunjaya, MD, Byers Eye Institute, Stanford University, Palo Alto, Calif.
    Photo by Ryan Imperio, CRA, OCT-C, andSean Grout, Duke Eye Center, Durham, N.C.

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    Toxoplasma Chorioretinitis

    A man in his 30s presented with floaters and pain in the right eye. Examination revealed keratic precipitates (KP), 1 to 2+ anterior segment and vitreous cells, Kyrieleis’ vasculitis, and active chorioretinitis with over­lying vitreous stranding next to an old, partially pigmented chorioretinal scar in the posterior pole. Corresponding enhanced-depth spectral domain optical coherence tomography (OCT) showed stippled vitreous hyperreflectivity and hyperreflec­tive thickening of the retina with disorganization of all layers atop choroidal thickening in the area of active infection, adjacent to an area of retinal thinning with associated dense vitreoretinal ad­hesion (Fig. 1). Systemic workup revealed positive toxoplasmosis IgG and IgM titers. A diagnosis of recurrent toxoplasmosis chorioretinitis was made, and the patient was treated with oral sulfamethoxazole-trimethoprim and topical prednisolone acetate drops. After the patient completed a 6-week antibiotic course, examination revealed resolution of active inflammation and scar formation. Corre­sponding OCT demonstrated retinal thinning with loss of retinal architecture (Fig. 2).

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