• Parts A–C courtesy of Tomas S. Aleman, MD; parts D and E courtesy of Sander Dubovy, MD.
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    Ocular Pathology/Oncology

    Adult-onset foveomacular vitelliform dystrophy. A, Fundus photograph shows a yellowish, egg yolk–like lesion with focal pigment clumping and mottling in the central macula. B, Near-infrared FAF image from the same patient shown in part A reveals increased autofluorescence corresponding to the vitelliform lesion (arrow). C, SD-OCT (same patient as in parts A and b<>(B) reveals subfoveal hyperreflective material (asterisk). Note the irregular RPE elevation (between arrowheads). D, Histologic findings include pigment-containing cells in the subretinal space (arrowheads) and outer neurosensory retina (arrow). E, Electron microscopy shows pigment-containing cells filled with lipofuscin (arrowheads).