Age-related macular degeneration (AMD). Top row: fundus autofluorescence (FAF) images with corresponding optical coherence tomography (OCT) horizontal B-scans in the bottom row. White lines show the approximate location of the B-scan. a. Nonexudative AMD with drusen. There is a homogeneous background FAF level and hypoautofluorescence in the fovea due to macular pigment (not due to atrophy). There is irregular hyper- and hypoautofluorescence due to multiple drusen. b. Geographic atrophy. In AMD, geographic atrophy is visible as well-demarcated areas of hypoautofluorescence due to the absence of the RPE. Blue and yellow arrows indicate the corresponding edges of atrophic areas between the autofluorescence image and the OCT B-scan. There is hyperautofluorescence in the junctional zone surrounding the atrophy, indicating elevated levels of lipofuscin (example circled in red). Note that the RPE in the fovea is intact (as seen on OCT B-scan) but appears hypoautofluorescent due to the blockage by luteal pigments (green arrows). c. Exudative AMD with subretinal fluid, subretinal hyperreflective material (purple arrows), and a pigment epithelial detachment. The FAF image shows a cartwheel pattern with mottled areas of hyper- and hypoautofluorescence.