Albinism. A, Iris transillumination. B, Fundus hypopigmentation. C, Photomicrograph illustrates decreased pigmentation in the iris pigment epithelium (smaller melanosomes) allowing visualization of the nuclei (white arrow). No appreciable pigmentation is present in the iris stroma (asterisk) (H&E stain). D, Photomicrograph shows RPE and choroid in an albino eye. Note the apical distribution of melanin granules and overall decreased pigmentation in the RPE (arrow), rare giant melanosomes (arrowhead) in the RPE, and lack of appreciable pigmentation in the choroidal stroma (asterisk) (H&E stain).