Best disease. A, Left eye with vitelliform lesion and central dome-shaped choroidal neovascular membrane (CNVM). B, Right eye with central macular hyperautofluorescence due to vitelliform material, as seen on FAF imaging. C, Fluorescein angiography image (right eye) reveals central macular hyperfluorescence due to staining of vitelliform material. D, Fluorescein angiography image (left eye) shows late central hyperfluorescence from leakage of CNVM. E, Spectral-domain OCT (SD-OCT) image (right eye) reveals subretinal hyperreflective material with a hyporeflective cleft corresponding to the vitelliform lesion. F, SD-OCT image (left eye) reveals a large subfoveal pigment epithelial detachment with subretinal hyperreflective material and subretinal fluid.