Central retinal artery occlusion (CRAO). A, Histologically, necrosis occurs in the inner retina (asterisk) corresponding to the retinal whitening observed on ophthalmoscopic examination. Note the pyknotic nuclei (arrows) in the inner aspect of the inner nuclear layer (H&E stain). B, SD-OCT reveals increased reflectivity in the area of retinal necrosis (asterisks). C, SD-OCT in remote CRAO in the same patient shown in B reveals attenuation of the inner retina (in brackets) with loss of the normal lamellar architecture up to the outer plexiform layer– outer nuclear layer junction. ELM = external limiting membrane, ONL = outer nuclear layer.