Coats disease. A, Leukocoria as a result of Coats disease. B, Total exudative retinal detachment in Coats disease. Note the dense subretinal proteinaceous fluid (asterisk) (H&E stain). C, Telangiectatic vessels (asterisks) and “foamy” macrophages (arrowhead) typical of Coats disease (H&E stain). D, High magnification of subretinal exudate showing lipid-laden and pigment-laden macrophages (arrows) and cholesterol clefts (arrowheads) (H&E stain).