Congenital hypertrophy of the RPE (CHRPE), various clinical appearances. A, Large, homogeneously black CHRPE lesion. B, CHRPE with atrophic lacunae. C, Grouped pigmentation of the RPE represents a variant of CHRPE. D, Appearance of the RPE hamartoma associated with familial adenomatous polyposis. Note the depigmented margins and comma shape (oval).