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  • Congenital hypertrophy of the RPE (CHRPE)

    Parts A and D courtesy of Alison Skalet, MD, PhD; parts B and C courtesy of Tero Kivelä, MD.
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    Ocular Pathology/Oncology
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    Congenital hypertrophy of the RPE (CHRPE), various clinical appearances. A, Large, homogeneously black CHRPE lesion. B, CHRPE with atrophic lacunae. C, Grouped pigmentation of the RPE represents a variant of CHRPE. D, Appearance of the RPE hamartoma associated with familial adenomatous polyposis. Note the depigmented margins and comma shape (oval).