Cytomegalovirus (CMV) retinitis. A, Retinal hemorrhages and areas of opaque retina are present. Note the vascular sheathing in the superotemporal arcade and hard exudates in the macular region. B, Histologically, full-thickness retinal necrosis is present. Note loss of the normal lamellar architecture of the retina, including disruption of the RPE (arrows) (H&E stain). C, Large syncytial cells (arrowheads) are present in areas of necrosis, characteristic of CMV retinitis (H&E stain). D, Intranuclear “owl’s eye” inclusions (arrows) and intracytoplasmic inclusions (arrowhead) are present in CMV-infected cells (H&E stain).