Lesions of the RPE. A, Reactive hyperplasia. B, Simple hamartoma. C, Clinical appearance and D, fluorescein angiogram of a peripapillary combined hamartoma of the retina and RPE. Note obscuration of the retinal vessels in superior aspect of the lesion, moderate deep pigmentation, and secondary hard exudates. The fluorescein angiogram shows the vascular component of the hamartoma, composed of small capillary-like telangiectatic vessels. Note the relative hypofluorescence superior to the optic nerve head due to the RPE component of this lesion.