• Courtesy of Richard F. Spaide, MD.
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    Multimodal imaging of refractile drusen and associated atrophy. A, Color fundus photograph of geographic atrophy with refractile drusen. B, Enlarging the section within the white square from A shows a remarkable amount of information, even the diamond-like particles that seem to correspond to hydroxyapatite spherules seen in histologic sections of drusen. C, Fundus autofluorescence (AF) image shows attenuated autofluorescence in areas of geographic atrophy also shown in the color photograph; it also reveals an absence of autofluorescence colocalizing in the locations of the refractile drusen.