OCT image generation overview. a. Basic schematic example of how OCTA images are generated. A baseline image is obtained, and rapidly afterward another image is obtained of the same tissue plane. Differences between these 2 images are evaluated, and any differences noted are flagged as areas of flow; an image that shows only where change was noted can then be generated. b. An example of OCTA image generation with retinal images. A baseline scan and a subsequent repeated scan of the same area are performed in rapid succession. These images are compared, and areas where changes occurred are highlighted (red dots). This process can then be repeated throughout the entire macula to generate a series of images. The images are then segmented, and difference maps for each segment are created to result in en face images of the retinal vasculature.