• Courtesy of Robert H. Rosa Jr, MD.
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    Ocular Pathology/Oncology

    Cystoid macular edema (CME) before and after therapy with anti‒vascular endothelial growth factor (anti-VEGF). A, SD-OCT shows mild CME (arrowhead), subretinal fluid (asterisks), and irregular elevation and detachment of the RPE (white arrow) secondary to neovascular age-related macular degeneration. Note the outer aspect of Bruch membrane (red arrows). B, SD-OCT of the same retina after anti-VEGF therapy shows resolution of the CME and detachment of the RPE. Focal areas of geographic atrophy of the RPE with attenuation of the photoreceptor cell layer are more apparent (between arrowheads). Note the hyperreflectivity (between dashed lines) in the choroid corresponding to the areas of geographic atrophy.