• Courtesy of Robert H. Rosa, Jr., MD; Part D courtesy of Chrstine A. Curcio, PhD.
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    Ocular Pathology/Oncology

    Reticular pseudodrusen. A, Color photograph shows ill-defined, yellowish, reticular pattern (between arrowheads) in the superior macula. B, Fundus autofluorescence (FAF) image shows corresponding region (between arrowheads) with dot-like areas of decreased and increased FAF. C, Near infrared image (upper panel) shows similar dot-like areas of decreased reflectance which, on SD-OCT (lower panel), correspond to deposits (arrows) interposed between the photoreceptor outer segments and RPE. Note the focal disruption of the ellipsoid zone. D, Subretinal druesnoid deposits (yellow areaheads) are the histologic correlate of reticular pseudodrusen. Note their location in the region of the outter segements HF = Henle fiber layer; ONL = outer nuclear layer; IS = inner segments; OS = Outher segments; RPE = retinal pigment epithelium; BrM = Bruch membrane; CH = choroid; Sc = sclera. Submicrometer expoxy section, toluidine blue stain, osmium paraphyenylediamine post-fixation.