Reproduced with permission from Sainz de la Maza M, Molina N, Gonzalez-Gonzalez LA, Doctor PP, Tauber J, Foster CS. Scleritis therapy. Ophthalmology. 2012;119(1):57
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Cornea/External Disease
Suggested guideline for the treatment of patients with scleritis. BRM = biologic response modifier; IMT = immunomodulatory therapy; NSAIDs = nonsteroidal anti-inflammatory drugs; SAIDs = steroidal anti-inflammatory drugs; TNF = tumor necrosis factor; >2+ = grading of level of scleral inflammation (by authors of this figure). *Consider BRM such as rituximab for ovarian protection. †Consider first IMT (antimetabolite agent). If therapeutic failure, consider BRM (anti-TNF‑a agent). If potentially lethal disease: alkylating agent IMT.