Endophthalmitis Reduction with Intracameral Moxifloxacin After Posterior Capsule Rupture

In this interview from AAO 2018, Dr. David F. Chang discusses postoperative endophthalmitis rates before and after intracameral moxifloxacin prophylaxis (ICMP) in eyes with posterior capsule rupture. Performed together with his colleague Aravind Haripriya, MBBS, the 6-year retrospective study assessed more than 1.5 million consecutive cataract surgeries at the 10 Aravind Eye hospitals in India. Eyes that did not receive ICMP had a greater than 3.5-fold higher rate of endophthalmitis than eyes that did receive antibiotics. ICMP also significantly reduced the endophthalmitis rate in more than 22,000 eyes with posterior capsular rupture. Dr. Chang concludes that this is the strongest evidence yet supporting this relatively inexpensive prophylactic therapy at the time of cataract surgery.

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