In this interview, Dr. Steve Charles reviews the current state of innovation in ophthalmology gleaned from the 2013 Ophthalmology Innovation Summit, a conference that joins clinicians, scientists, industry experts, regulatory agencies, and venture capitalists. The conference is a rare and important opportunity for the various parties to partner collaboratively toward moving innovation ahead in an economic and regulatory climate that offers both challenges and opportunities. A vitreoretinal surgeon, entrepreneur, and engineer, Dr. Charles shares the most promising innovations in ophthalmology, including large-molecule therapeutics, minimally invasive surgical devices, and applications for OCT-guided femtosecond laser.