In this interview from AAO 2014, Dr. Sunir Garg discusses his research using deep DNA sequencing to identify potential pathogens in culture-negative endopthalmitis. Dr. Garg and colleagues found Torque teno virus at high levels in culture-negative endophthalmitis, which raises the possibility that it may play a role in the condition. Torque teno virus is associated with a host of inflammatory diseases, including multiple sclerosis and lupus, and is a known cause of seasonal hyperacute panuveitis syndrome. The investigators hope to learn whether the virus is a direct intraocular pathogen or resides in the bloodstream and enters the eye through a breakdown in the blood/retinal barrier.