• The American Academy of Ophthalmology IRIS® Registry (Intelligent Research In Sight) represents a remarkable opportunity for knowledge discovery and collaborative studies. The world’s largest specialty clinical data registry, the IRIS Registry has aggregated, de-identified data on over 166 million patient visits from 41 million unique patients, growing daily. Over 13,000 clinicians in ophthalmology practices have registered to electronically contribute their data to the IRIS Registry through their electronic health record systems.

    How It Works 

    EHR data is stripped of all unique patient identifiers when it is uploaded into IRIS Registry for privacy purposes. Participating physicians own their own data. The Academy owns the de-identified, aggregated data and can analyze these data. The database has the same legal protections and safeguards from legal discoverability, as do hospital-based peer-review processes.

    Ways to Use Our Data 

    The IRIS Registry’s database can help to inform the natural history of diseases, prevalence of rare diseases, practice patterns, diffusion of technology, comparative effectiveness and more, all in the real-world setting. Data elements include: patient demographics, patient medical and ocular history, clinical examination findings, diagnoses, procedures and medications.

    As an example, the registry currently contains data on the following disease conditions:

    • The rate of endophthalmitis after cataract surgery, the visual outcome of patients with endophthalmitis and specific risk factors associated with developing endophthalmitis
    • The rate of endophthalmitis after anti-VEGF injections across different agents and the comparative effectiveness of these agents based on visual acuity outcomes
    • The prevalence of myopic choroidal neovascularization in the United States, based on both diagnostic code information and clinical data
    • The treatment patterns for patients with myopic choroidal neovascularization, including the visual acuity outcomes for those treated and those not treated

    Current research opportunities 

    IRIS Registry Data Dictionary

    The IRIS Registry database is comprised of data extracted from participants’ electronic health record systems. Review the registry’s data dictionary, which includes data variables accessible for analysis in the IRIS Registry: Coming Soon

    IRIS Registry Publications

    The 2016 American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) Database:  Characteristics and Methods
    Michael F. Chiang, MD, et al
    Ophthalmology, in press (published online Jan. 15, 2018)

    Performance Rates Measured in the IRIS Registry
    William L. Rich III, MD  et al.
    Ophthalmology, in press (published online Jan. 15, 2018)

    The Real World Effect of Intravitreous Anti-VEGF Drugs on IOP: An Analysis Using the IRIS Registry
    Elizabeth Atchison, MD et al.
    Ophthalmology, in press (published online Jan. 11, 2018)

    Real World Vision in Age-Related Macular Degeneration Patients Treated with Bevacizumab, Ranibizumab or Aflibercept only Over One Year in a Cohort of the IRIS Registry
    Prethy Rao, MD, et al
    Ophthalmology, in press (published online Nov. 13, 2017)

    The American Academy of Ophthalmology’s IRIS Clinical Data Registry: A Look Back and a Look to the Future
    David W. Parke II, MD et al.
    Ophthalmology Volume 124, Issue 11, 1572-1574 (November 2017)

    Treatment Patterns for Myopic Choroidal Neovascularization in the United States
    Willis, Jeffrey et al.
    Ophthalmology, Volume 124, Issue 7, 935 - 943 (July 2017)

    The Prevalence of Myopic Choroidal Neovascularization in the United States
    Willis, Jeffrey R. et al.
    Ophthalmology, Volume 123, Issue 8, 1771 - 1782 (August 2016)

    How Big Data Informs Us About Cataract Surgery: The LXXII Edward Jackson Memorial Lecture
    Coleman, Anne Louise
    American Journal of Ophthalmology, Volume 160, Issue 6, 1091 - 1103.e3 (December 2015)

    Parke II DW 2nd, Lum, F, Rich WL.  The IRIS Registry:  Purpose and Perspectives.  Ophthalmologe 2017; 114(Suppl):1-6. 

    Willis JR, Vitale S, Morse L, Parke II DW 2nd, Rich WL, Lum F, Cantrell RA:  The Prevalence of Myopic Choroidal Neovascularization in the United States:  Analysis of the IRIS Data Registry and NHANES.  Ophthalmology 2016; 123:1771-82.

    Willis J, Morse L, Vitale S, Parke DW 2nd, Rich WL, Lum F, Cantrell RA.  Treatment Patterns for Myopic Choroidal Neovascularization in the United States:  Analysis of the IRIS Registry.  Ophthalmology 2017; 124:935-943.

    Chiang MF, Sommer A, Rich WL, Lum F, Parke DW 2nd.  The American Academy of Ophthalmology IRIS Registry (Intelligent Research in Sight) Database:  Characteristics and Methods.  Ophthalmology. 2018 Jan 13. pii: S0161-6420(17)32703-3. doi: 10.1016/j.ophtha.2017.12.001. [Epub ahead of print]

    Parke DW 3rd, Lum F.  Return to the Operating Room after Macular Surgery:  IRIS Registry Analysis. Ophthalmology  2018 Feb 14 pii: S0161-6420(17)33178-0. doi: 10.1016/j.ophtha.2018.01.009. [Epub ahead of print]

    Repka MX, Lum F, Burugapalli B.  Strabismus, Strabismus Surgery and Reoperation Rate in the United States:  Analysis from the IRIS Registry.  Ophthalmology. 2018 May 17. pii: S0161-6420(18)30484-6. doi: 10.1016/j.ophtha.2018.04.024. [Epub ahead of print]