- Choroidal metastases are the most common intraocular tumors.
- Sixty-six percent (66%) of patients have a known history of carcinoma at the time of diagnosis of the choroidal metastasis, while 34% present with no known history of cancer. In up to 10% of patients, no primary cancer is discovered even after workup.
- The most common primary tumor locations are the breast and lung (Table 1).
- Upon diagnosis of choroidal metastases, more than 50% of patients are found to have other sites of metastatic spread, most commonly the lung.
- Prognosis is poor with a median survival time of 6-12 months.
Table 1: Frequency of Primary Cancer Site in Men and Women with Metastasis to the Choroid
GI Tract (9%)
GI Tract (2%)
Little region-specific data is available on the incidence of choroidal metastases geographically. The available data suggests that the primary cancer sites of choroidal metastases closely resemble the frequency of cancers in the population studied; that is, the most common cancers are also the most commonly associated with choroidal metastases. Thus, it is likely that the site of the primary tumor from choroidal metastases will vary geographically based on the cancers most frequently encountered in a given region.
- The mechanism of intraocular metastasis is via hematogenous dissemination of tumor cells.
- Arterial blood supply to the eye dictates the primary sites of tumor deposition within the eye.
- Given the rich vascular supply to the posterior choroid, it is the most favored site of intraocular metastasis.
- The posterior ciliary arteries provide a greater flow for tumor emboli to the posterior choroid than the fewer, lower flow anterior ciliary vessels to the anterior uvea (iris and ciliary body).
- Likewise, the optic nerve and retina are rarely exclusively involved, given that they are supplied typically by a single vessel (central retinal artery).
Medical history, clinical exam, and noninvasive testing are typically sufficient to reach a diagnosis.
The metastases are usually asymptomatic. However, depending on the location within the choroid, the patient may experience visual symptoms, most commonly blurred vision.
- Elevated plaque-like choroidal lesions with indistinct borders
- Usually yellow in color
- Pink or bright orange if primary tumor is renal cell carcinoma, thyroid carcinoma
- Brown or tan if metastatic cutaneous melanoma
- Usually larger than the optic disc in diameter
- Over 90% of lesions are in the posterior pole
- Up to 50% of cases exhibit bilateral choroidal lesions, and almost 33% present with
more than one lesion in an eye
- Frequently associated with exudative retinal detachment (occurs in 88% of patients) (Figure 7)
- B-scan generally shows a subretinal echogenic mass with ill-defined borders
- A-scan generally shows mass with medium to high internal reflectivity, little vascularity, and a solid consistency
Fluorescein angiography (FA)
- Little intratumoral vascularity
- Blocked choroidal fluorescence in early phase, diffuse leaks in late phase
Other Testing Methods
- Magnetic resonance imaging (MRI) and computed tomography (CT) imaging have little usefulness in diagnosing a choroidal tumor. They may show a mass, but they are not sufficiently sensitive or specific to be more helpful than a clinical examination.
- Fine-needle aspiration biopsy can be used in some choroidal lesions. It can be considered if the primary tumor cannot be located (to obtain a diagnosis to facilitate appropriate treatment selection) but surgery should be approached carefully.
The treatment of choroidal metastasi s requires a multidisciplinary team composed of an ophthalmologist, an oncologist, and a radiation oncologist.
The diagnosis of choroidal metastasi s of a known cancer should prompt an appropriate work up to restage the disease and treat other sites of metastases appropriately. In the majority of cases of choroidal metastases, other sites of metastases are also found, most commonly the lung.
- In as many as 34% of cases of choroidal metastasi s, there is no known primary cancer at the time of diagnosis.
- Initiation of appropriate systemic chemotherapy or other targeted therapies to treat the primary tumor is frequently the first step in management of choroidal metastases. Because the choroid is external to the blood-aqueous and blood-retinal barriers, penetration of systemic agents to the choroid is usually good, especially due to the highly fenestrated nature of the choroidal vasculature. Moreover, such systemic therapies concurrently treat other sites of metastases, which are frequently noted at the time of diagnosis of the choroidal metastasis.
- Local therapies may be more appropriate if the choroid is the only site of metastases, or if the choroidal lesions fail to respond to appropriate systemic chemotherapies.
The following local treatment modalities are used depending on availability:
- Radiation therapy (by far the treatment of choice)
- External-beam radiation
- Proton beam radiation
- Brachytherapy (Figure 8)
- Photodynamic therapy
- Transpupillary thermotherapy (TTT)
- Laser photocoagulation (Figure 7)
- Enucleation (in cases of severe, unrelenting pain)
The treatment options for choroidal metastasis may depend on the extent of involvement:
- Diffuse metastatic disease
- Hormonal therapy (for hormone-dependent tumors)
- Immune modulation
- Anti-VEGF agents
- Hospice care for terminally ill
- Focal/local disease
- Local disease
- Surgical treatment for painful eyes with secondary glaucoma
CASE STUDY: Rural Africa
History of Present Illness
- The patient presented for evaluation of blurry vision OD, gradually progressing over several months
- The patient had a history of trauma OS as a child, with subsequent no light perception (NLP) vision
Past Medical History
- Worked as a farmer; 45-year history of smoking
- Visual acuity was 20/60 OD, NLP OS
- Anterior segment evaluation revealed visually significant cataract OD, consistent with the patient’s symptoms and visual acuity
- Dilated fundus examination revealed a 3DD dome-shaped yellow choroidal lesion OD in the posterior pole, above the superotemporal arcade
- Ultrasound revealed that the lesion OD was dome-shaped with medium to high internal reflectivity
- A diagnosis of choroidal metastasis OD was made
- The patient had no known history of cancer. A careful clinical history was undertaken and revealed a recent 12-pound unintentional weight loss and chronic cough. He was referred to the closest hospital that had an oncologist and imaging capabilities.
- Workup for a primary tumor, including chest, abdomen, and pelvis CT scan, revealed multiple pulmonary nodules consistent with lung cancer. CT scan also showed several enlarged lymph nodes and a metastatic lesion in the left adrenal gland.
- In collaboration with the oncologist, a decision was made to treat initially with systemic chemotherapy to address both the primary tumor and the multiple metastatic foci, including the choroidal lesion. The patient was followed during and after chemotherapy; examinations revealed regression of the metastatic choroidal lesion during chemotherapy.
- One year after initial diagnosis, however, examination revealed a new choroidal lesion in the temporal retina (not involving the fovea) OD.Restaging imaging revealed widespread metastatic disease. (Figures 9, 10)
- After discussing treatment options with his oncologist, a decision was made to forego further chemotherapy and treat palliatively.
- Upon follow-up, the temporal choroidal metastatic lesion grew. In order to prevent encroachment into the fovea and preserve vision in this monocular eye, external-beam radiation was administered to this lesion. This resulted in regression and preservation of vision until the patient died from widespread metastatic disease several months later.
Figure 1. Choroidal melanoma. (© 2013 American Academy of Ophthalmology)
Figure 2. Choroidal osteoma. (Reprinted, with permission, from Albert DM, Miller JW, Azar DT, Blodi BA, Cohan JE, Perkins T. Albert & Jakobiec's Principles & Practice of Ophthalmology. 3rd ed. Philadelphia: WB Saunders; 2008.)
Figure 3. Choroidal hemangioma. (© 2013 American Academy of Ophthalmology)
Figure 4. Disciform scar. (© 2013 American Academy of Ophthalmology)
Figure 5. Rhegmatogenous retinal detachment. From Rao et al. Internal limiting membrane peeling for primary rhegmatogenous retinal detachment repair. Ophthalmology. 2013; 120(5): 1102-1103.
Figure 6. Posterior scleritis (© 2013 American Academy of Ophthalmology)
Figure 7. Choroidal detachment following panretinal photocoagulation for the management of diabetic retinopathy. (Image courtesy of M. Gilbert Grand, MD.)
Figure 8. Choroidal melanoma treated by radioactive brachytherapy. (Left) Mildly elevated remnants of melanoma surrounded by atrophic chorioretinal scarring, nasal to the optic nerve head. (Right) Flat remnants of melanoma pigmentation surrounded by chorioretinal scarring located temporal to the macula. (Images courtesy of Jacob Pe’er, MD.)
Figure 9. (Left) Mushroom-shaped pigmented choroidal melanoma with initial thickness of 7.5 mm before iodine-125 plaque radiotherapy. (Right) There is surrounding lipid exudation and serous RD 16 months after plaque radiotherapy; note involvement of the fovea by lipid exudation accounting for visual acuity of 20/200. (Reproduced from Mashayekhi A, Tuncer S, Shields CL, Shields JA. Tumor-related lipid exudation after plaque radiotherapy of choroidal melanoma: the role of Bruch’s membrane rupture. Ophthalmology. 2010; 117 (5): 1013-1023.)
Figure 10. (Left) Pigmented choroidal melanoma with initial thickness of 5.0 mm and no visible Bruch's membrane rupture at initial presentation; FNAB of tumor for cytogenetic studies was performed at time of application of iodine-125 radioactive plaque. (Middle) Four months after plaque radiotherapy, focal area of Bruch's membrane rupture is visible at site of needle biopsy. (Right) Nine months after radiotherapy, lipid exudation is noticeable at the inferior margin of the tumor; there is radiation- induced chorioretinal atrophy at the anterior and lateral margins of the tumor. FNAB = fine-needle aspiration biopsy. (Reproduced from Mashayekhi A, Tuncer S, Shields CL, Shields JA. Tumor-related lipid exudation after plaque radiotherapy of choroidal melanoma: the role of Bruch’s membrane rupture. Ophthalmology. 2010; 117 (5): 1013-1023.)
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R. V. Paul Chan, MD, FACS, Weill Cornell Medical College, New York, New York
Dupe Ademola-Popoola, MBBS, FMCOphth, FWACS, Department of Ophthalmology, University of Ilorin
Jeff Pettey, MD, University of Utah Department of Ophthalmology and Visual Sciences, John Moran Eye Center's Residency Program Director
Grace Sun, MD, Weill Cornell Eye - Lower Manhattan, Weill Cornell Medical College Residency Program Director
Samir Patel, BS, Weill Cornell Medical College, New York, New York
Peter Coombs, MD, Weill Cornell Medical College; New York, New York
American Academy of Ophthalmology
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