A patient presents with unilateral visual loss with a relative afferent pupillary defect, pericentral scotoma, and sectoral retinal pigmented epithelial atrophy. The initial differential diagnosis of gradual, unilateral visual loss is quite broad and includes epiretinal membrane, vitreomacular traction, macular hole, central serous chorioretinopathy, dry AMD, macular edema, toxoplasmosis, presumed ocular histoplasmosis, diffuse unilateral subacute neuroretinitis, sarcoidosis, Vogt-Koyanagi-Harada syndrome, posterior scleritis, serpiginous chorioretinopathy, autoimmune retinopathy, retinitis pigmentosa and allied disorders, medication toxicity, cone-rod dystrophy, Best disease, Stargardt disease, macular telangiectasia, white-dot syndromes (AZOOR), vitamin A deficiency, cancer-associated retinopathy, melanoma-associated retinopathy, ocular melanoma, radiation-induced retinopathy, glaucoma, cerebral meningioma, aneurysm, optic nerve meningioma/glioma, toxic optic neuropathy, nutritional optic neuropathy, and hereditary optic neuropathy.