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  • Part A courtesy of Sander Dubovy, MD; part C courtesy of Hans E. Grossniklaus, MD; part D courtesy of Tatyana Milman, MD; part E courtesy of George J. Harocopos, MD.
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    Ocular Pathology/Oncology

    Keratoconus. A, Clinical appearance. B, Low-magnification view shows apical stromal thinning (arrow). C, Masson trichrome stain demonstrates focal disruption of Bowman layer (arrow). D, Prussian blue stain demonstrates intraepithelial iron deposition (Fleischer ring). E, In a patient with prior hydrops, PAS stain highlights rupture of Descemet membrane, with rolled-up edges on either side (arrows).