Ocular coloboma. Color photographs of the left eye of the same patient. The embryonic fissure correlates to the inferior nasal aspect of the eye. Colobomas of different ocular structures arise in this axis when the fissure fails to close. A, Anterior segment photograph demonstrating iris coloboma. The red reflex also demonstrates irregular development of the inferior lens equator and absence of zonules. B, Fundus photograph demonstrating coloboma in the inferior nasal quadrant with absence of retina and choroid. The optic nerve is also enlarged.