Examples of cotton-wool spots. A, Wide-field color fundus photograph of the right eye shows multiple fluffy, ill-defined white parapapillary lesions consistent with cotton-wool spots. Their superficial location is demonstrated by the obscuration of retinal vessels by some of the larger lesions. B, Fundus photograph shows an isolated cotton-wool spot just outside the superotemporal macula of the right eye. C, OCT through the lesion in B shows hyperreflectivity in the inner retina.