Submacular hemorrhage. A, Color fundus photograph from a 74-year-old man with 2 days of vision loss and 20/400 visual acuity. Note the lighter-appearing blood in the sub–retinal pigment epithelium (sub-RPE) space in the center and temporal macula versus the darker-appearing blood in the subretinal space in the nasal macula and inferior retina. B, Spectral-domain OCT vertical line scan through the macula shows inferior (left) subretinal hemorrhage and central sub-RPE hemorrhage. Sub-RPE hemorrhage is not amenable to pneumatic displacement; thus, the patient was treated with intravitreal anti–vascular endothelial growth factor (anti-VEGF) alone, and visual acuity improved to 20/60.