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    Can You Guess January's Mystery Condition?

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    Make your diagnosis in the comments, and look for the answer in next month’s Blink.

    January 2021 Blink


    Last Month’s Blink

    Acute Posterior Multifocal Placoid Pigment Epitheliopathy

    Written by Travis S. Dowdle, BS, at Texas Tech University Health Sciences Center School of Medicine, Lubbock, and Bryan K. Monson, MD, at Monson Vision, Logan, Utah. Photo by Bryan K. Monson, MD.

    December 2020 Blink

    A 25-year-old man presented to the clinic with a history of five days of bilateral increasingly blurred and diminished vision and floaters. He stated that approximately one month earlier he had had a serious virus that caused moderate diarrhea and that the illness spread through his family. His visual acuity (VA) was counting fingers at five feet in the right eye, 20/250 in the left, and 20/200 bilaterally.

    He had multiple cream-colored chorioretinal plaque lesions throughout the posterior pole bilaterally on slit-lamp microscopy (Figs. 1, 2). During OCT imaging, subneurosensory retinal fluid was discovered bilaterally at the macula (Figs. 3, 4), and a fluorescein angiogram showed early blockage with late hyperfluorescence. After consulting with vitreoretinal and uveitis specialists, we put the patient on a 60-mg daily oral prednis­olone taper regimen for six weeks. Because these signs and symptoms can be associated with cere­bral vasculitis, the patient had an MRI. However, the neurological evaluation came back negative. The patient’s vision improved significantly over the six-week period, and his VA was 20/25 in both eyes during follow-up.

    This patient was diagnosed with acute posterior multifocal placoid pigment epitheliopathy (AP­MPPE), an inflammatory condition of the retinal pigment epithelium. Most of these patients see resolution of their symptoms without treatment, but approximately 20% can have persisting symp­toms and a VA of 20/40 or worse after six months.

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