In response to the steady increase of prescription opioid misuse, the FDA has required a Risk Evaluation and Mitigation Strategy (REMS) for Extended Release/Long Acting (ER/LA) and Immediate Release (IR) opioid analgesics. Physician and other clinician education is an important part of this strategy. Below are resources and CME activities intended to reinforce proper prescribing practices and improve clinicians' recognition of opioid abuse signs. These may also help meet state-level opioid CME requirements.