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  • Journal Highlights

    MIS for Orbital Tumors, Link Between RVO and Dementia, and More


    Effects of Pupillary Dilation in PAC Suspects With Cataract

    Brolucizumab Outcomes at 96 Weeks

    OCT Retinal Thickness Map Detects HCQ Retinopathy

    Ophthalmology Retina

    Return to the OR After Vitrectomy for Vitreous Opacities

    American Journal of Ophthalmology

    Minimally Invasive Surgery for Intraconal Orbital Tumors

    RVO Raises the Risk of Dementia

    JAMA Ophthalmology

    Sensory Impairment Is Linked to Perceived Discrimination

    Visual Outcomes of Children With Optic Neuritis

    Vitamin D3, Omega-3 Fatty Acids, and AMD Risk

    Other Journals

    Diagnosing Pediatric Orbital Cellulitis: CT or rMRI?

    Thrombolysis for Central Retinal Artery Occlusion

    IRIS Registry Snapshot: Switching Anti-VEGF Drugs in DME

    Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetic retinopathy and can appear at any stage of the disease. Cur­rent treatment involves intravitreal injections of anti-VEGF agents; ophthalmologists typi­cally start with one drug and switch to a different agent when the clinical response is suboptimal.

    Verana Health assessed switching patterns by ana-lyzing statistically de-identified electronic health record data from the Acad­emy’s IRIS (Intelligent Research in Sight) Registry. A switcher was defined as an eye that had at least three injections of one agent and then had a different agent at a subsequent visit. Eyes without specified laterality were excluded.

    Of the 202,532 treated eyes with DME, 19,083 (94.2%) were switched to another anti-VEGF drug between Jan. 1, 2016, and Dec. 31, 2019. Of these, 65.7% were switched to aflibercept.

    Aflibercept and ranibizumab net gained 9,325 and 1,613 eyes, respectively, whereas bevacizumab lost 10,941 eyes to switching.

    Aflibercept and ranibizumab gained most of their switches from bevacizumab (83.1% and 63.7%, respectively).

    Sankey Diagram

    SANKEY DIAGRAM. Switching patterns of anti-VEGF agents in DME.


    Note: The Academy has partnered with Verana Health to curate and analyze IRIS Registry data.