Drusen occur naturally with age. The exact relationship between degenerative macular disease and drusen is not clear. However, having large drusen is a sign of AMD.
Most people with drusen do not have any symptoms. Often, a routine eye exam will incidentally reveal their presence. Small drusen are not a symptom of eye disease. However, the presence of a large number of large drusen is an early sign of dry age-related macular degeneration (AMD). The symptoms of AMD include hazy vision, difficulty seeing when going from bright light to low light, and a blank or blurry spot in your central vision.
Optic nerve drusen also often do not produce symptoms. However, some patients with optic nerve drusen experience vision problems, including loss of peripheral (side) vision and temporary flickering or graying out of their vision.