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  • American Academy of Ophthalmology Applauds UnitedHealthcare for Clarifying Drug Policy on Ophthalmic Avastin Alternatives

    SAN FRANCISCO — The Academy commends UnitedHealthcare (UHC) for acting quickly to clarify its policy regarding the use of two biosimilars untested for ophthalmic/intravitreal use as alternatives to the sight-saving drug Avastin. UHC removed the drugs, Mvasi and Zirabev, from the maximum dosing policy and the anti-VEGF commercial policy, effective Aug. 6. The Academy supports this action to protect our patients and hopes other insurers will follow UHC’s lead.

    A recent supply chain disruption that limited Avastin’s availability has led several large healthcare insurers to list the two biosimilars as alternatives. This development has alarmed ophthalmologists because these drugs have never been tested in the eye. They are not approved for intravitreal injection and their labels do not include treatment of eye disease. Even the drug’s manufacturers, Pfizer and Amgen, have not recommended the use of their biosimilars in the eye.

    The Academy met with UHC two weeks ago to discuss our concern that the drugs are inappropriate alternatives for patients who need intravitreal anti-VEGF treatment. Anti-VEGFs are critically important treatment options for patients facing vision-threatening diseases, such as age-related macular degeneration, macular edema, neovascular glaucoma and others. We appreciate the insurer’s willingness to listen to our position and to clarify policy language to protect patients.

    The other insurers have yet to announce any change in their policies. The Academy continues to discuss with the Centers for Medicare & Medicaid Services and the U.S. Department of Health and Human Services the necessity of prohibiting the drugs for ophthalmic use in policies for Medicare Advantage and exchange plans. 


    About the American Academy of Ophthalmology
    The American Academy of Ophthalmology is the world’s largest association of eye physicians and surgeons. A global community of 32,000 medical doctors, we protect sight and empower lives by setting the standards for ophthalmic education and advocating for our patients and the public. We innovate to advance our profession and to ensure the delivery of the highest-quality eye care. Our EyeSmart® program provides the public with the most trusted information about eye health. For more information, visit